| Cat. No. |
Product Name |
Information |
| PC-28061 |
ARN24139
Topoisomerase II inhibitor
|
ARN24139 (ARN-24139) is a potent topoisomerase II (Topo II) inhibitor with IC50 of 7.3 uM, shows high cytotoxicity in cancer cell lines (DU145, HeLa, A549) with IC50 of 3.1-4.7 uM. |
| PC-27615 |
TopBP1 inhibitor CS18
TopBP1-BRCT7/8 inhibitor
|
TopBP1 inhibitor CS18 is a potent and selective C-terminal BRCT7/8 domains of topoisomerase IIβ-binding protein 1 (TopBP1) inhibitor, competes with pS1159 peptide for binding to TopBP1-BRCT7/8 with IC50 of 2.47 nM. |
| PC-25441 |
(S)-10-Hydroxycamptothecin
Topo I inhibitor, DHHC9 inhibitor
|
(S)-10-Hydroxycamptothecin (10-HCPT, 10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor with remarkable apoptosis-inducing effect, also is a potent DHHC9 inhibitor that effectively suppressed adenocarcinoma cell migration. |
| PC-24768 |
Topobexin
TOP2B inhibitor
|
Topobexin is a selective Topoisomerase IIβ (TOP2B) catalytic inhibitor with IC50 of 0.19 uM in DNA decatenation assays, 25-fold selective over TOP2A (IC50=4.8 uM). |
| PC-23976 |
Irinotecan
Topo I inhibitor
|
Irinotecan ((+)-Irinotecan, CPT-11) is a topoisomerase I (Top I, TOP1) inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex. |
| PC-22288 |
Genz-644282
Topo I inhibitor
|
Genz-644282 is a potent, non-camptothecin topoisomerase I (Top1) inhibitor, shows potent activities against a panel of human tumor cell lines with IC50 of 1.8 nM-1.8 uM. |
| PC-49305 |
Doxorubicin hydrochloride
Topoisomerase inhibitor
|
Doxorubicin hydrochloride is a 14-hydroxylated version of Daunorubicin, Doxorubicin is an antitumor antibiotic agent, is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50 of 0.8 μM and 2.67 μM, respectively. |
| PC-38577 |
ARN-21934
Topo IIα inhibitor
|
ARN-21934 is a potent, highly selective human topoisomerase II α (Topo IIα) with IC50 of 2 μM for inhibition of DNA relaxation, 100-fold selectivity for topo IIα over Topo β. |
| PC-72675 |
HH-N25
Topo I inhibitor
|
HH-N25 is a a potent and selective topoisomerase I (TOP1) inhibitor with potent antiproliferative activities against a panel of human breast cancer cell lines (IC50=0.045-4.2 uM). |
| PC-72442 |
LMP744
Topo I inhibitor
|
LMP744 (MJ-III-65, NSC706744) is a small molecule TOP1 inhibitor antitumoral activity. |
| PC-72441 |
LMP517
TOP1/2 inhibitor
|
LMP517 (NSC 781517) is a non-camptothecin, dual TOP1 and TOP2 topoisomerase inhibitor. |
| PC-38245 |
Lapcin
Topoisomerase inhibitor
|
Lapcin is a potent dual topoisomerase I/II inhibitor with nM to pM IC50s against diverse cancer cell lines (Colon cancer HT29 cell IC50=0.516 nM). |
