| Cat. No. |
Product Name |
Information |
| PC-42639 |
Betulinic acid
Topo II inhibitor
|
Betulinic acid (Betulic acid) is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties. |
| PC-42643 |
Voreloxin
Topo II inhibitor
|
Voreloxin (SNS-595;Vosaroxin;AG 7352) is a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II, exhibits proliferation inhibition of AML cell lines MV4-11 and HL-60 with IC50 of 95 nM and 884 nM, respectively. |
| PC-28737 |
Topotecan hydrochloride
Topoisomerase I inhibitor, RPL15 binder
|
Topotecan hydrochloride is (SKF104864A, NSC 609669) is an orally active topoisomerase I (TOP1) inhibitor, induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis in mutiple cancer cells, also inhibits preribosomal subunit formation via binding to RPL15, activates STING-mediated antitumor immune responses. |
| PC-28736 |
Topotecan
Topoisomerase I inhibitor, RPL15 binder
|
Topotecan is (SKF104864A, NSC 609669) is an orally active topoisomerase I (TOP1) inhibitor, induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis in mutiple cancer cells, also inhibits preribosomal subunit formation via binding to RPL15, activates STING-mediated antitumor immune responses. |
| PC-28326 |
(±)-10-Hydroxycamptothecin
Topo I inhibitor
|
(±)-10-Hydroxycamptothecin ((±)-10-HCPT) is an indole alkaloid that inhibits the activity of topoisomerase I (Topo I), shows broad spectrum of anticancer activity. |
| PC-28248 |
Doxorubicin
Topoisomerase inhibitor
|
Doxorubicin (Hydroxydaunorubicin) is a cytotoxic anthracycline antibiotic with anti-cancer chemotherapy activity, is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50 of 0.8 μM and 2.67 μM, respectively. |
| PC-28247 |
Berubicin hydrochloride
Topo II inhibitor
|
Berubicin hydrochloride (WP744, RTA744) is a doxorubicin analog that can penetrate and cross the blood-brain barrier, preserving DNA binding and acting as a potent topoisomerase II poison. |
| PC-28246 |
Berubicin
Topo II inhibitor
|
Berubicin (WP744, RTA744) is a doxorubicin analog that can penetrate and cross the blood-brain barrier, preserving DNA binding and acting as a potent topoisomerase II poison. |
| PC-27848 |
Camptothecin
Topo I inhibitor
|
Camptothecin (CPT) is a kind of alkaloid and potent specific DNA topoisomerase I (Topo I) inhibitor with IC50 of 679 nM, exhibits broad antineoplastic activity against multiple cancers. |
| PC-27641 |
Chrysosplenetin
CAS 603-56-5
|
Chrysosplenetin is an o-methylated flavonols isolated from the leaves of Laggera pterodonta with anti-cancer effect, shows strong activity in vitro against EV71 with IC50 of 0.2 uM, also shows neuraminidase inhibitory activity, inhibits topoisomerase I and II. |
| PC-27536 |
Etoposide
Topo II inhibitor, CD44 inhibitor
|
Etoposide (VP-16-213) is a topoisomerase II inhibitor that disrupts DNA replication and transcription, induces cell cycle arrest, apoptosis and autophagy, also inhibits Hyaluronic acid (HA)-CD44 interaction. |
| PC-25511 |
Banoxantrone dihydrochloride
Topo II inhibitor
|
Banoxantrone dihydrochloride (AQ4N) is an alkylaminoanthraquinone-di-N-oxide anticancer prodrug, potentiates the anti-tumour effect of cisplatin, AQ4N is metabolised in hypoxic cells by cytochrome P450s (CYPs) to the cytotoxin AQ4, which is a stable, DNA-affinic compound and potent topoisomerase II inhibitor. |
