| Cat. No. |
Product Name |
Information |
| PC-35639 |
STA-8666
Topo I inhibitor
|
STA-8666 (STA8666, STA-21-8666, PEN-866) is a novel HSP90 inhibitor/SN-38 drug conjugate (HDC), a potent topoisomerase I inhibitor and pharmacologically active metabolite of irinotecan, STA-8666 is cleaved by carboxylesterase (CES) to release SN-38. |
| PC-63536 |
Indotecan
Topo I inhibitor
|
Indotecan (LMP400) is an anticancer DNA Topoisomerase I (Top1) inhibitor, inhibits P388, HCT116, MCF-7 cell lines with IC50 of 300, 1200, 560 nM respectively. |
| PC-63535 |
Indimitecan
Topo I inhibitor
|
Indimitecan (LMP776, NSC 725776) is an anticancer DNA Topoisomerase I (Top1) inhibitor, shows antiproliferative activities against various human cancer cell lines. |
| PC-63054 |
Idarubicin
Topo II inhibitor
|
Idarubicin (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells. |
| PC-62442 |
BNS-22
Topo II inhibitor
|
BNS-22 is a small-molecule inhibitor of DNA topoisomerase II, inhibits kinetoplast DNA decatenation that is mediated by human TOP2α and TOP2β in vitro with IC50 of 2.8 and 0.42 uM, respectively. |
| PC-61905 |
Epolactaene
Topo II inhibitor
|
Epolactaene is a neuritogenic fungal isolate that arrests the cell cycle at the G0/G1 phase and induces the outgrowth of neurites in human neuroblastoma SH-SY5Y cells. |
| PC-61874 |
XR-5000
Topoisomerase inhibitor
|
XR-5000 (Acridine Carboxamide;DACA;NSC 601316;SN-22995) is an inhibitor of topoisomerase I and II for treatment of various types of cancers. |
| PC-61465 |
C-1311 dihydrochloride
Topo II inhibitor
|
C-1311 dihydrochloride (Imidacrine, Imidazoacridone) is an imidazoacridinone analogue with potent in vivo antitumour activity, inhibits the catalytic activity of Topoisomerase II. |
| PC-60558 |
GPX-150
Topo II inhibitor
|
GPX-150 (DIDOX, 5-imino-13-deoxy-doxorubicin) is a doxorubicin analog that demonstrates anti-cancer activity without cardiotoxicity, does not inhibit topoisomerase IIβ activity at 100 uM. |
| PC-45667 |
SW044248
Topo I inhibitor
|
SW044248 is a potent, selective inhibitor of Topoisomerase I (Topo I), inhibits Top I differently from camptothecin, shows selective toxicity for some NSCLC cell lines. |
| PC-45203 |
Idarubicin hydrochloride
Topo II inhibitor
|
Idarubicin hydrochloride (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells. |
| PC-42763 |
Amonafide
Topo II inhibitor
|
Amonafide (AS1413) is a small molecule topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA. |
