| Cat. No. |
Product Name |
Information |
| PC-25414 |
RhoA inhibitor CL16
RhoA inhibitor
|
RhoA inhibitor CL16 is a specific small molecule covalent RhoA inhibitor with binding IC50 of 440 nM, targets the unique Cys16 on RhoA subfamily, effectively disrupts GTP binding and inhibits RhoA activity in CRC cells. |
| PC-24945 |
RAC1 inhibitor A41
RAC1 inhibitor
|
RAC1 inhibitor A41 is a potent, specific and reversible inhibitor of RAC proteins, competes with guanine nucleotide binding, inhibits RAC1-dependent membrane ruffle formation with IC50 of 2.5 nM. |
| PC-22520 |
ARN25499
Cdc42 inhibitor
|
ARN25499 is a potent, selective inhibitor of CDC42 GTPases (CDC42, RHOJ, RHOQ), exhibits s antiproliferative activity of melanoma cancer cell lines that have a BRAFV600E mutation (SKM28, SKMel3, WM3248, A375) with IC50 of 8-13.5 uM. |
| PC-20881 |
PREX-in1
P-Rex inhibitor
|
PREX-in1 is a specific small-molecule inhibitor of P-Rex1 and P-Rex2 Rac-GEF activity with IC50 of 4.5 uM (P-Rex1 DHPH Rac-GEF activity) in liposome-based GEF assay, inhibits P-Rex1 and P-Rex2 through their catalytic DH domain. |
| PC-20183 |
GYS32661
RAC1 inhibitor
|
GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays. |
| PC-20011 |
Rho GTPase inhibitor O1
Rho inhibitor
|
Rho GTPase inhibitor O1 is a small molecule RhoA GTPase inhibitor, perturbs mitotic progression in fission yeast. |
| PC-49776 |
Phox-I2
p67phox-Rac1 inhibitor
|
Phox-I2 is a specific small molecule inhibitor of Rac1-p67phox interaction, binds to the Rac1 interactive site of p67phox specifically (Ki=150 nM) and interferes with Rac1-GTP interaction with p67phox. |
| PC-49214 |
CS7171
Rac1 inhibitor
|
CS7171 is an effective, blood-brain barrier (BBB) permeable small molecule inhibitor of hippocampal Rac1 activity, rescues learning deficits in APP/PS1 mice. |
| PC-49213 |
JKF-034
Rac1 inhibitor
|
JKF-034 is an effective,blood-brain barrier (BBB) permeable small molecule inhibitor of hippocampal Rac1 activity, rescues learning deficits in APP/PS1 mice. |
| PC-49212 |
EHT1864
Rac inhibitor
|
EHT1864 is a small molecule Rac inhibitor that blocks the Rac1 signaling pathways with IC50 of 5 uM in cellular luciferase assays, binds to Rac1b and Rac2 with very similar affinities (50 and 60 nM, respectively). |
| PC-38721 |
1D-142
RAC1 inhibitor
|
1D-142 is a novel small molecule RHO family of GTPase RAC1 inhibitor, inhibits Rac1-GEF interaction and reduces Rac1-mediated TNFα-induced NF-κB nuclear translocation during cell proliferation and migration. |
| PC-38507 |
RBC10
Ral GTPase inhibitor
|
RBC10 is a small molecule that target the Ral GTPase, inhibits Ral binding to its effector RalBP1, Ral-mediated cell spreading in murine fibroblasts and anchorage-independent growth of human cancer cell lines. |
