| Cat. No. |
Product Name |
Information |
| PC-43132 |
Rhosin hydrochloride
RhoA inhibitor
|
Rhosin (G04) is a potent, specific RhoA subfamily Rho GTPases inhibitor that specifically binds to RhoA to inhibit GEF reaction of RhoA with Kd of 0.4 uM, does not interact with Cdc42 or Rac1, nor the LARG. |
| PC-62791 |
BQU-082
GTPase Ral inhibitor
|
BQU-082 is a novel potent small GTPase Ral (Ras-like) inhibitor with IC50 of 1.7 uM, displays a dose dependent effect on RalA and RalB activity in H2122 spheroids using the common RalBP1 pull-down assay. |
| PC-62562 |
TBOPP
DOCK1 inhibitor
|
TBOPP is a selective inhibitor of Rac-specific guanine nucleotide exchange factor DOCK1, inhibits DOCK1-mediated Rac activation with IC50 of 8.4 uM. |
| PC-62515 |
Rheb inhibitor NR1
Rheb inhibitor
|
Rheb inhibitor NR1 is a small molecule that binds Rheb in the switch II domain (IC50=2.1 uM, Kd=1.5 uM) and selectively blocks mTORC1 signaling, potently inhibits mTORC1 driven phosphorylation of S6K1 but does not inhibit phosphorylation of AKT or ERK. |
| PC-62450 |
CPYPP
DOCK2-Rac1 inhibitor
|
CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction. |
| PC-62448 |
Phox-I1
p67phox-Rac1 inhibitor
|
Phox-I1 is a specific small molecule inhibitor of Rac1-p67phox interaction, binds to the Rac1 interactive site of p67phox specifically (Ki=100 nM) and interferes with Rac1-GTP interaction with p67phox. |
| PC-62365 |
ML282
Rab7 inhibitor
|
ML282 (CID 1067700) is a competitive small molecule inhibitor of nucleotide binding by Ras-related GTPases, binds the nucleotide binding pocket of Rab7 with Ki value of 13 nM. |
| PC-61470 |
Rac1-IN-6
Rac1 inhibitor
|
Rac1-IN-6 is a selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 88±48 nM. |
| PC-61469 |
Rac1-IN-1
Rac1 inhibitor
|
Rac1-IN-1 is a selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 95±21 nM. |
| PC-61468 |
MLS000532223
Rho GTPases inhibitor
|
MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases with EC50 of 16-120 uM. |
| PC-61174 |
SecinH3
Cytohesin GEFs inhibitor
|
SecinH3 is a selective inhibitor of small GEFs of the cytohesin family, blocks human, mouse and Drosophila cytohesins with IC50 of 2.4 to 5.6 uM. |
| PC-60905 |
MBQ-167
Rac/Cdc42 inhibitor
|
MBQ-167 (MBQ 167, MBQ167) is a potent, dual Rac/Cdc42 inhibitor with IC50 of 103/78 nM, respectively, in metastatic breast cancer cells. |
