Bragsin2 (Bragsin 2)

Chemical Structure : Bragsin2

CAS No.: 342795-08-8

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货号: PC-36078Not For Human Use, Lab Use Only.

Bragsin2 (Bragsin 2) is a specific inhibitor of the ArfGEF BRAG2, affects the trans-Golgi network in a BRAG2- and Arf-dependent manner in cells (IC50=3 uM).

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg		Get quote

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生物&药学活性

Bragsin2 (Bragsin 2) is a specific inhibitor of the ArfGEF BRAG2, affects the trans-Golgi network in a BRAG2- and Arf-dependent manner in cells (IC50=3 uM).
Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer to render BRAG2 unable to activate lipidated Arf, requires membranes for specific inhibition of BRAG2.
Bragsin2 affects tumorsphere formation in breast cancer cell lines.
Bragsin1 and Bragsin 2 are novel compounds that function by altering protein-membrane interactions without disruption.

物理化学性质&存储条件

分子量	289.166
分子式	C11H6F3NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-methoxy-5-nitro-2-(trifluoromethyl)-4H-chromen-4-one

参考文献

1. Nawrotek A, et al. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3.