RhoA inhibitor CL16

Chemical Structure : RhoA inhibitor CL16

加入收藏

货号: PC-25414Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

RhoA inhibitor CL16 is a specific small molecule covalent inhibitor with binding IC50 of 440 nM, targets the unique Cys16 on RhoA subfamily, effectively disrupts GTP binding and inhibits RhoA activity in CRC cells.
CL16 exhibits high specificity over other Rho family proteins, shows no observable binding with Rac1 and Cdc42.
CL16 binding with RhoA Cys16 prohibits RhoA-GTP binding and RhoA-GEF interactions.
CL16 (10 uM) is more effective than Rhosin (Cat# PC-43133) on inhibition of RhoA activity in CRC cells.
CL16 exhibits anticancer and antimetastatic effects on CRC through RhoA downregulation, has cytotoxic IC50 of 3.32 uM for HCT116 cells, but not normal colon fibroblast CCD-18Co cells.
CL16 (10 mg/kg, i.p. injection) significantly inhibited tumor growth of HCT116 xenograft, HT29 xenograft and SW620 xenograft.

物理化学性质&存储条件

分子量	328.75
分子式	C17H13ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-(benzofuran-2-yl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-2-chloroethan-1-one

参考文献

1. Koo TY, et al. Cell Chem Biol. 2025 Sep 2:S2451-9456(25)00255-7.