| Cat. No. |
Product Name |
Information |
| PC-45476 |
K-Ras G12C-IN-1
KRAS G12C inhibitor
|
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C. |
| PC-28768 |
RO7783903
KRAS G12C inhibitor
|
RO7783903 (RO3903) is a covalent KRAS G12C tricomplex inhibitor, over comes secondary KRAS mutations that drive clinical resistance to guanosine diphosphate (GDP)-bound (OFF) state inhibitors. |
| PC-27893 |
SCH51344
Ras/Rac inhibitor, MTH1 inhibitor
|
SCH51344 (SCH 51344) is a potent inhibitor of RAS transformation, specifically blocks membrane ruffling induced by activated forms of H-RAS, K-RAS, N-RAS and RAC, also potently inhibits MTH1 (NUDT1) with IC50 of 215 nM, 410 nM, and 675 nM for MTH1 substrates dGTP, 8-oxo-dGTP, and 2-OH-dATP. |
| PC-27417 |
Debecarasib
KRAS G12D inhibitor
|
Debecarasib is a potent and orally bioavailable inhibitor of GDP-bound KRAS G12D, shows highly selectivity for KRAS G12D against wild-type KRAS and other RAS mutations or amplifications. |
| PC-27366 |
AM-2383
pan-KRAS inhibitor
|
AM-2383 is a potent, selective pan-KRAS inhibitor that blocks signaling via both the GDP(off)- and GTP(on)-bound states of KRAS, potently bind to a diverse set of common oncogenic KRAS mutants with IC50 of 2-10 nM in NanoBRET KRAS target engagement assay, also potently bind to KRAS WT (IC50=2 nM). |
| PC-27036 |
JMKX1899
KRAS G12C inhibitor
|
JMKX1899 is a potent and selective, covalent, BBB-penetrating KRAS G12C inhibitor. |
| PC-26521 |
SOS1 inhibitor SL43
SOS1 inhibitor
|
SOS1 inhibitor SL43 is a potent, selective and orally bioavailable SOS1 inhibitor with binding KD of 0.16 uM, potently disrupts the SOS1-KRASG12C interaction with IC50 of 13 nM, broadly inhibits SOS1-mediated nucleotide exchange on multiple KRAS mutants (G12C, G12V and G12D; IC50 = 13.4-29.1 nM). |
| PC-26395 |
XMU-MP-9
K-RAS mutants degrader
|
XMU-MP-9 is bifunctional, specific small molecule K-RAS mutants degrader, facilitates NEDD4-1-mediated ubiquitination and degradation of various oncogenic K-RAS mutants. |
| PC-26309 |
BI-1830
KRAS G12D inhibitor
|
BI-1830 is a specific small molecule KRAS(G12D)-D92C binder, binds to D92-adjacent pocket stabilizes KRAS and inhibits signaling, inhibits phospho-ERK levels in KRAS(G12D)-D92C cells. |
| PC-25991 |
KRAS G12C inhibitor compound 8
KRAS G12C inhibitor
|
KRAS G12C inhibitor compound 8 is a potent, specific KRAS G12C dual inhibitor with IC50 of 10 nM (GDP Exchange Inhibition) and 133 nM (RAS/RAF Disruption), covalently modifies both KRAS G12C inactive and active states. |
| PC-25960 |
PDE6δ-IN-2
PDEδ inhibitor
|
PDE6δ-IN-2 is a potent, small molecule PDE6δ (PDE6delta, PDE6D) inhibitor with KD of <30 nM in displacement assays, inibits binding of PDE6δ to farnesylated Ras proteins and inhibits oncogenic Ras signaling in cells. |
| PC-25959 |
PDE6δ-IN-1
PDEδ inhibitor
|
PDE6δ-IN-1 is a potent, small molecule PDE6δ (PDE6delta, PDE6D) inhibitor with KD of <30 nM in displacement assays, inibits binding of PDE6δ to farnesylated Ras proteins and inhibits oncogenic Ras signaling in cells. |
