RO7783903 | KRAS G12C inhibitor | Probechem Biochemicals

Chemical Structure : RO7783903

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RO7783903 (RO3903)

货号: PC-28768Not For Human Use, Lab Use Only.

RO7783903 (RO3903) is a covalent KRAS G12C tricomplex inhibitor, over comes secondary KRAS mutations that drive clinical resistance to guanosine diphosphate (GDP)-bound (OFF) state inhibitors.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

RO7783903 (RO3903) is a covalent KRAS G12C tricomplex inhibitor, over comes secondary KRAS mutations that drive clinical resistance to guanosine diphosphate (GDP)-bound (OFF) state inhibitors.

物理化学性质&存储条件

分子量	1030.27
分子式	C55H77F2N9O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N1CCC(C(N([C@@H](C(C)C)C(N[C@H]2C(N3N[C@](CCC3)([H])C(OCC(C)(CC4=C(C5=C([C@H](C)OC)N=CC=C5)N(CC)C6=CC(F)=C(N7CCO[C@@H](C2)C7)C=C46)C)=O)=O)=O)C)=O)(CC1)F)C#CC(C)(C)N(C)C

参考文献

1. Xiangyu Yao, et al. Proc Natl Acad Sci U S A. 2026 Nov 10;123(45):e2621263123.

RO7783903 (RO3903)

生物&药学活性

物理化学性质&存储条件

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RO7783903 (RO3903)

生物&药学活性

物理化学性质&存储条件

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