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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ras-BI-1830
BI-1830

Chemical Structure : BI-1830

CAS No.:

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BI-1830

货号: PC-26309Not For Human Use, Lab Use Only.

BI-1830 is a specific small molecule KRAS(G12D)-D92C binder, binds to D92-adjacent pocket stabilizes KRAS and inhibits signaling, inhibits phospho-ERK levels in KRAS(G12D)-D92C cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BI-1830 is a specific small molecule KRAS(G12D)-D92C binder, binds to D92-adjacent pocket stabilizes KRAS and inhibits signaling, inhibits phospho-ERK levels in KRAS(G12D)-D92C cells.

物理化学性质&存储条件

分子量 366.26
分子式 C16H20BrN3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-((4-bromo-2-methylphenyl)glycyl)piperazin-1-yl)prop-2-en-1-one

参考文献

1. van Tienen LM, et al. Cell Chem Biol. 2026 Feb 19;33(2):241-255.e8.

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