| Cat. No. |
Product Name |
Information |
| PC-27036 |
JMKX1899
KRAS G12C inhibitor
|
JMKX1899 is a potent and selective, covalent, BBB-penetrating KRAS G12C inhibitor. |
| PC-26521 |
SOS1 inhibitor SL43
SOS1 inhibitor
|
SOS1 inhibitor SL43 is a potent, selective and orally bioavailable SOS1 inhibitor with binding KD of 0.16 uM, potently disrupts the SOS1-KRASG12C interaction with IC50 of 13 nM, broadly inhibits SOS1-mediated nucleotide exchange on multiple KRAS mutants (G12C, G12V and G12D; IC50 = 13.4-29.1 nM). |
| PC-26395 |
XMU-MP-9
K-RAS mutants degrader
|
XMU-MP-9 is bifunctional, specific small molecule K-RAS mutants degrader, facilitates NEDD4-1-mediated ubiquitination and degradation of various oncogenic K-RAS mutants. |
| PC-26309 |
BI-1830
KRAS G12D inhibitor
|
BI-1830 is a specific small molecule KRAS(G12D)-D92C binder, binds to D92-adjacent pocket stabilizes KRAS and inhibits signaling, inhibits phospho-ERK levels in KRAS(G12D)-D92C cells. |
| PC-26225 |
BBO-11818
KRAS inhibitor
|
BBO-11818 is a potent, selective, orally bioavailable noncovalent pan-KRAS inhibitor, potently disrupts the interaction of RAF1-RAS Binding Domain (RBD) with KRASG12D (IC50=28 nM), KRASG12V (IC50=61 nM), KRASG12C (IC50=47 nM), and KRASG12R (IC50=51 nM), as well as KRASWT (IC50=120 nM). |
| PC-25991 |
KRAS G12C inhibitor compound 8
KRAS G12C inhibitor
|
KRAS G12C inhibitor compound 8 is a potent, specific KRAS G12C dual inhibitor with IC50 of 10 nM (GDP Exchange Inhibition) and 133 nM (RAS/RAF Disruption), covalently modifies both KRAS G12C inactive and active states. |
| PC-25960 |
PDE6δ-IN-2
PDEδ inhibitor
|
PDE6δ-IN-2 is a potent, small molecule PDE6δ (PDE6delta, PDE6D) inhibitor with KD of <30 nM in displacement assays, inibits binding of PDE6δ to farnesylated Ras proteins and inhibits oncogenic Ras signaling in cells. |
| PC-25959 |
PDE6δ-IN-1
PDEδ inhibitor
|
PDE6δ-IN-1 is a potent, small molecule PDE6δ (PDE6delta, PDE6D) inhibitor with KD of <30 nM in displacement assays, inibits binding of PDE6δ to farnesylated Ras proteins and inhibits oncogenic Ras signaling in cells. |
| PC-25585 |
C4-180
RALGEF inhibitor
|
C4-180 is a potent, specific small molecule pan-RALGEF (Ras-like small GTPases exchange factors) inhibitor, specifically inhbits RAL but not MAPK/AKT signaling, impairs the interaction of RALGEFs with RAS. |
| PC-25521 |
SHY-867
Ras inhibitor
|
SHY-867 (SHY867) is a potent, non-covalent small molecule inhibitor of pan-Ras superfamily, competes with GTP binding to K-Ras WT, the G12D, G12C and Q61H mutants, as well as Rac-1 and Rho-A, with IC50 values of 1.25-5.0 uM. |
| PC-25520 |
SHY-855
Ras inhibitor
|
SHY-855 (SHY855) is a potent, non-covalent small molecule inhibitor of pan-Ras superfamily, competes with GTP binding to K-Ras WT, the G12D, G12C and Q61H mutants, as well as Rac-1 and Rho-A, with IC50 values of 2.5-5 uM. |
| PC-25265 |
MCB-294
KRAS inhibitor
|
MCB-294 is a potent, selective, dual-state pan-KRAS inhibitor capable of binding both the active (GTP-bound) and inactive (GDP-bound) forms of KRAS, effectively inactivates both wild-type KRAS and multiple KRAS mutants. |
