| Cat. No. |
Product Name |
Information |
| PC-21164 |
IRX4647
RARγ agonist
|
IRX4647 is a selective RARγ agonist, regulates T cell biology and reduces syngeneic tumor growth of immune checkpoint-resistant lung cancer cell line (344SQ) when combined with anti-PD-L1. |
| PC-21162 |
AGN196996
RARα antagonist
|
AGN 196996 (IRX6696) is a potent selective RARα antagonist with Ki of 2 nM, shows little to no activity against RARβ and RARγ. |
| PC-21041 |
Tamibarotene
RARα agonist
|
Tamibarotene (Am80, SY-1425) is a potent and selective retinoic acid receptor α (RARα) agonist with high selectivity over RARγ, exhibits anti-angiogenic activity. |
| PC-20839 |
XS-060
RXRα inhibitor
|
XS-060 is a small molecule RXRα-targeted anti-mitotic agent, binds to RXRα (Kd=1.3 uM) and selectively inhibits the p-RXRα/PLK1 interaction to induce mitotic arrest and catastrophe in cancer cells. |
| PC-20831 |
PA452
RXR antagonist
|
PA452 is a specific antagonist of retinoic X receptor (RXR) with pA2 value of 7.11. |
| PC-20830 |
LG101506
RXR modulator
|
LG101506 (LG1506) is a potent, selective and orally active RXR modulator with Ki of 2.6 nM. |
| PC-20829 |
CD3254
RXR agonist
|
CD3254 (CD 3254) is a potent and selective RXR agonist with EC50 of 13 nM. |
| PC-20776 |
HX531
RXR antagonist
|
HX531 is a potent, pan RXR antagonist with IC50 of 18 nM on retinoidal activity in HL-60 cell assays, HX531 also is a partial PPARγ inhibitor and ameliorates diet-induced obesity and type 2 diabetes. |
| PC-20775 |
IRX4204
RXR agonist
|
IRX4204 (AGN194204) is a potent, specific and brain penetrable pan-RXR agonist, fully activates all three RXRs (α, β and γ) at 1 nM, activates nuclear receptor Nurr1 downstream signaling. |
| PC-20769 |
Bexarotene
RXR agonist
|
Bexarotene (LGD1069) is a highly potent and selective retinoid X receptors (RXR) agonist with EC50 of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ respectively, with no affinity for RAR receptors. |
| PC-20433 |
Amsilarotene
RARα inhibitor
|
Amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity, shows selective affinity for RARα with binding Ki of 2.4 nM. |
| PC-20205 |
AGN194310
pan-RAR inhibitor
|
AGN194310 (VTP-194310) is a highly potent, pan-RAR antagonist with binding Kd value of 2-5 nM, inhibits prostate carcinoma lines LNCaP, PC3 and DU145 with IC50 of 16-34 nM. |
