LG101506 | RXR modulator | Probechem Biochemicals

Chemical Structure : LG101506

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LG101506 (LG 101506, LG1506)

货号: PC-20830Not For Human Use, Lab Use Only.

LG101506 (LG1506) is a potent, selective and orally active RXR modulator with Ki of 2.6 nM.

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生物&药学活性

LG101506 (LG1506) is a potent, selective and orally active RXR modulator with Ki of 2.6 nM.
LG101506 binds RXRalpha and activates RXR homo and heterodimers.
LG1506 is a potent insulin sensitizer that also enhances the insulin-sensitizing activities of rosiglitazone.
Administration of LG1506 reduces both body weight gain and food consumption and blocks the TZD-induced weight gain when coadministered with rosiglitazone.
LG1506 does not significantly suppress the thyroid hormone axis in rats, nor does it elevate triglycerides in Sprague Dawley rats.
LG1506 elevates high-density lipoprotein cholesterol in humanized apolipoprotein A-1-transgenic mice.

物理化学性质&存储条件

分子量	420.54
分子式	C25H34F2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E,4E,6Z)-7-(3,5-di-tert-butyl-2-(2,2-difluoroethoxy)phenyl)-3-methylocta-2,4,6-trienoic acid

参考文献

1. Leibowitz MD, et al. Endocrinology. 2006 Feb;147(2):1044-53.

2. Gernert DL, et al. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3191-5.

LG101506 (LG 101506, LG1506)

生物&药学活性

物理化学性质&存储条件

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LG101506 (LG 101506, LG1506)

生物&药学活性

物理化学性质&存储条件

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