| Cat. No. |
Product Name |
Information |
| PC-27573 |
Abbapolin 12
PLK1 PBD inhibitor
|
Abbapolin 12 is a nonpeptidic inhibitor of PLK1 polo-box domain (PBD) with IC50 of 26.8 uM in FP assays, inhibits viability in PC3 prostate cancer cells with IC50 of 15 uM. |
| PC-27332 |
ZSL-M028
PLK4 inhibitor
|
ZSL-M028 is a potent and selective, orally active Polo-like kinase 4 (PLK4) inhibitor with IC50 of 1.1 nM, has 1600-fold selectivity over Aurora A, demonstrates significant in vitro and in vivo antitumor activity against TRIM37-amplified neuroblastoma. |
| PC-25788 |
PLK1 inhibitor 31
PLK1 inhibitor
|
PLK1 inhibitor 31 is a highly potent, selective polo-like kinase 1 (PLK1) inhibitor with IC50 of <0.5 nM, shows potent antiproliferative activity against a variety of cancer cell lines with IC50 of 11.1 nM for HCC cell line HepG2. |
| PC-24927 |
MLN0905
PLK1 inhibitor
|
MLN0905 is a potent, selective and orally bioavailable inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 2 nM. |
| PC-24639 |
RP-1664
PLK4 inhibitor
|
RP-1664 (RP1664) is a potent, selective and orally available inhibitor of PLK4 with IC50 of 3 nM, >1900-fold selective over Aurora A/B. |
| PC-22312 |
NMS-P937
PLK1 inhibitor
|
NMS-P937 (Onvansertib, NMS-1286937) is a potent, selective and orally available PLK1 inhibitor with IC50 of 2 nM. |
| PC-21081 |
Allopole
PLK1 PBD inhibitor
|
Allopole is the first allosteric, specfic and cell-permeable inhibitor of the noncatalytic polo-box domain (PBD) of PLK1 (Polo-like kinase 1), Allopole is the prodrug of Allopole-A. |
| PC-21080 |
Allopole-A
PLK1 PBD inhibitor
|
Allopole-A is the first allosteric, specfic inhibitor of the noncatalytic polo-box domain (PBD) of PLK1 (Polo-like kinase 1) with IC50 of 2.5 nM in FP-based assays, Allopole-A is the active form of Allopole. |
| PC-20477 |
MCC1019
PLK1 PBD inhibitor
|
MCC1019 is a selective inhibitor of PLK1, targets PLK1 Polo box domain (PBD) with binding IC50 of 16.4 uM, 2.75-fold over PLK2-PBD (IC50=44.1 uM) and > 6-fold higher specificity over PLK3 PBD (IC50 >100 uM). |
| PC-73207 |
ON1231320
PLK2 inhibitor
|
ON1231320 is a highly specific, ATP-mimetic polo-like kinase 2 (PLK2) inhibitor with IC50 of 0.31 uM. |
| PC-35728 |
YLT-11
PLK4 inhibitor
|
YLT-11 (PLK4 inhibitor YLT11) is a novel potent, selective, ATP-competitive PLK4 inhibitor with IC50 of 22 nM, Kd of 5.2 nM. |
| PC-63238 |
CFI-400945 fumarate
PLK4 inhibitor
|
CFI-400945 (Ocifisertib) fumarate is a potent, highly selective, orally available PLK4 inhibitor with Ki of 0.26 nM and IC50 of 2.8 nM, does not significantly inhibits PLK1/2/3 at 50 uM. |
