Abbapolin 12

Chemical Structure : Abbapolin 12

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货号: PC-27573Not For Human Use, Lab Use Only.

Abbapolin 12 is a nonpeptidic inhibitor of PLK1 polo-box domain (PBD) with IC50 of 26.8 uM in FP assays, inhibits viability in PC3 prostate cancer cells with IC50 of 15 uM.

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生物&药学活性

Abbapolin 12 is a nonpeptidic inhibitor of PLK1 polo-box domain (PBD) with IC50 of 26.8 uM in FP assays, inhibits viability in PC3 prostate cancer cells with IC50 of 15 uM.
Abbapolin 12 binds to PLK1 with an EC50 0.65 μM to PLK1 in cellular thermal shift assays.
Abbapolin 12 (0-45 uM) blocks PLK1 phosphorylation of TCTP on Ser46 in asynchronous PC3 cells.
Abbapolin 12 induces PLK1 degradation in prostate cancer cell line DU145.
Abbapolin 12 demonstrate antiproliferative activity in cells that are dramatically resistant to ATP-competitive PLK1 inhibitors.

物理化学性质&存储条件

分子量	399.55
分子式	C23H29NO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Methyl-2-[[4-(octylthio)benzoyl]amino]benzoic acid

参考文献

1. Danda Chapagai, et al. J Med Chem. 2021 Jul 22;64(14):9916-9925.

Abbapolin 12

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Abbapolin 12

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