| Cat. No. |
Product Name |
Information |
| PC-23432 |
Prazosin
MT3 receptor antagonist
|
Prazosin is an α-adrenergic receptor antagonist, and selective MT3 melatonin receptor antagonist. |
| PC-23430 |
Luzindole
Melatonin receptor antagonist
|
Luzindole (N-0774) is a potent, selective melatonin receptor antagonist with Ki of 10.2 nM and 158 nM for human MT2 and MT1, respectively. |
| PC-38133 |
UCSF7447
MT-1 inverse agonist
|
UCSF7447 (UCSF-7447, ZINC555417447) is a potent, selecive, brain permeable melatonin receptor MT-1 inverse agonist with Ki of 304 nM (hMT-1). |
| PC-61335 |
Piromelatine
Melatonin receptor/5-HT agonist
|
Piromelatine (Neu-P11) is a melatonin melatonin receptor MT1/MT2 and serotonin 5-HT1A/5-HT1D receptor agonist. |
| PC-45162 |
Agomelatine L( )-Tartaric acid
|
A melatonin receptor agonist of MT1 (Ki=0.1nM) and MT2 (Ki=0.12nM), and a 5-HT2C (Ki=631nM) receptor antagonist. |
| PC-45161 |
Agomelatine hydrochloride
Melatonin receptor agonist
|
Agomelatine hydrochloride (S-20098) melatonin receptor agonist of MT1 (Ki=0.1nM) and MT2 (Ki=0.12nM), and a 5-HT2C (Ki=631nM) receptor antagonist. |
| PC-45160 |
Agomelatine
Melatonin receptor agonist
|
Agomelatine (S-20098) is a melatonin receptor agonist of MT1 (Ki=0.1nM) and MT2 (Ki=0.12nM), and a 5-HT2C (Ki=631nM) receptor antagonist. |
| PC-26840 |
8-M-PDOT
Melatonin receptor MT2 agonist
|
8-M-PDOT (AH-002, 8MP) is a high affinity, selective melatonin MT2 receptor agonist with pKi value of 8.25, has anxiolytic-like activity |
| PC-26839 |
GR128107
Melatonin receptor antagonist
|
GR128107 is a high affinity, competitive melatonin receptor antagonist with pKi of 9.6, shows substantially higher affinities for MT2 receptor, 23 fold selective over MT1. |
| PC-26838 |
4-P-PDOT
Melatonin receptor MT2 antagonist
|
4-P-PDOT is a potent, selective and high affinity melatonin receptor MT2 antagonist with pEC50 of 8.72 inhibition of forskolin stimulated cyclic AMP, >300-fold more selective for MT2 than MT1. |
| PC-26547 |
S22153
Melatonin receptor antagonist
|
S-22153 is a potent melatonin receptor antagonist with EC50 of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. |
| PC-26382 |
ASP5633
MT1/MT2 receptor agonist
|
ASP5633 is potent, highly selective peripherally restricted melatonin MT1/MT2 receptor agonist with EC50 of 12.3, 18.6, 36.2 and 36.4 nM for human MT1, human MT2, rat MT1 and rat MT2 by Ca2+ flux assays. |
