| Cat. No. |
Product Name |
Information |
| PC-28775 |
Z1268663363
IL-6/IL-6R inhibitor
|
Z1268663363 is a small molecule IL-6 signaling inhibitor, directly binds IL-6R (SPR Kd=14.83 uM) and disrupts IL-6/IL-6R interaction. |
| PC-28774 |
Z1268663684
IL-6/IL-6R inhibitor
|
Z1268663684 is a small molecule IL-6 signaling inhibitor, directly binds IL-6R (SPR Kd=8.27 uM) and disrupts IL-6/IL-6R interaction. |
| PC-26677 |
Anakinra
IL-1R antagonist
|
Anakinra (AMG719, AMG-719, Raleukin) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. |
| PC-26288 |
KYH1943
IL-33 antagonist
|
KYH1943 is a specific small-molecule inhibitor targeting IL-33/ST2 signaling, suppresses IL-33-induced Treg activation and proliferation. |
| PC-26149 |
IRA10L
IL-36R inhibitor
|
IRA10L is a specific small molecule inhibitor of IL-36 receptor (IL-36R), inhibits IL-36-induced hCXCL1 secretion in HT29 cells with IC50 of 4.72 µM for IL-36γ, 5.81 µM for IL-36α, 14.55 µM for IL-36β, and 6.49 µM for the IL-36α/β/γ cocktail. |
| PC-25547 |
4L2-P13D
IL-11 antagonist
|
4L2-P13D is a potent, high-affinity macrocyclic peptide antagonist of interleukin-11 (IL-11) with binding KD of 11 nM and IC50 of 2.8 uM, shows significant renoprotective effects and antirenal fibrosis both in vitro and in vivo. |
| PC-21192 |
hIL-1β antagonist Compound (S)-2
hIL-1β antagonist
|
Compound (S)-2 is a specific antagonist of the hIL-1β /IL-1R1 (human interleukin-1β/IL-1R1) interaction with IC50 of 4.0 uM in TR-FRET assays, binds hIL-1β with SPR Kd of 1.1 uM. |
