Z1268663363

Chemical Structure : Z1268663363

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货号: PC-28775Not For Human Use, Lab Use Only.

Z1268663363 is a small molecule IL-6 signaling inhibitor, directly binds IL-6R (SPR Kd=14.83 uM) and disrupts IL-6/IL-6R interaction.

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100 mg		Get quote

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生物&药学活性

Z1268663363 is a small molecule IL-6 signaling inhibitor, directly binds IL-6R (SPR Kd=14.83 uM) and disrupts IL-6/IL-6R interaction.
Z1268663363 suppressed IL-6-induced STAT3, JAK1, JAK2, ERK1/2, and gp130 phosphorylation and inhibited IL-6-dependent TF-1 cell proliferation in RAW264.7 cells.
Z1268663363 dose-dependently suppressed SARS-CoV-2 and IAVs-induced STAT3 activation.

物理化学性质&存储条件

分子量	285.35
分子式	C16H19N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(benzo[d][1,3]dioxol-4-yl)-N-((5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-8-yl)methyl)methanamine

参考文献

1. Jingyi Yang, et al. J Adv Res. 2026 Nov 11:S2090-1232(26)00891-X.

Z1268663363

生物&药学活性

物理化学性质&存储条件

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Z1268663363

生物&药学活性

物理化学性质&存储条件

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