| Cat. No. |
Product Name |
Information |
| PC-35897 |
LMT-28
IL-6 inhibitor
|
LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130. |
| PC-63195 |
RCGD423
gp130 modulator
|
RCGD423 (RCGD-423) is a small molecule gp130 modulator that prevents articular cartilage degeneration and promotes repair both in vitro and in vivo. |
| PC-62479 |
SP4206
IL-2α receptor inhibitor
|
SP4206 is a high-affinity (Kd=70 nM) small molecule that blocks the binding of the IL-2α receptor (IL-2Rα) to IL-2. |
| PC-45128 |
Suplatast tosilate
Th2 cytokine inhibitor
|
Suplatast tosilate (IPD-1151T) is a Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN-γ production. |
| PC-45769 |
YM-90709
IL-5 receptor inhibitor
|
YM-90709 (YM90709) is a potent IL-5 receptor antagonist that inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells with IC50 of 1.0 and 0.57 uM, respectively. |
| PC-25755 |
JNJ627
IL-17A inhibitor
|
JNJ627 (JNJ-627) is a small-molecule allosteric inhibitor of the IL-17A homodimer, inhibits IL-17A binding to IL-17RA with IC50 of 16 nM in TR-FRET assays. |
| PC-25547 |
4L2-P13D
IL-11 antagonist
|
4L2-P13D is a potent, high-affinity macrocyclic peptide antagonist of interleukin-11 (IL-11) with binding KD of 11 nM and IC50 of 2.8 uM, shows significant renoprotective effects and antirenal fibrosis both in vitro and in vivo. |
| PC-25197 |
SMI-10B13
Oncostatin M inhibitor
|
SMI-10B13 is a first-in-class, small molecule inhibitor of Oncostatin M (OSM) with Kd of 6.6 uM, strongly inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines with IC50 of 136 and 164 nM, respectively. |
| PC-25141 |
IA-0130
gp130 inhibitor
|
IA-0130 a specific glycoprotein 130 (gp130, IL-6Rβ) inhibitor with SPR KD of 2.8 uM, interfers with the interaction between IL-6 and gp130, inhibits IL-6/gp130/STAT3 pathway activity. |
| PC-23454 |
IRI-1
IL-1R1/IL-1β inhibitor
|
IRI-1 is a specific interleukin-1 receptor I (IL-1R1)/interleukin 1β (IL-1β) interaction inhibitor with IC50 of 5.15 uM. |
| PC-21192 |
hIL-1β antagonist Compound (S)-2
hIL-1β antagonist
|
Compound (S)-2 is a specific antagonist of the hIL-1β /IL-1R1 (human interleukin-1β/IL-1R1) interaction with IC50 of 4.0 uM in TR-FRET assays, binds hIL-1β with SPR Kd of 1.1 uM. |
