RCGD423 | gp130 modulator | Probechem Biochemicals

Chemical Structure : RCGD423

CAS No.: 108237-91-8

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RCGD423 (RCGD-423)

货号: PC-63195Not For Human Use, Lab Use Only.

RCGD423 (RCGD-423) is a small molecule gp130 modulator that prevents articular cartilage degeneration and promotes repair both in vitro and in vivo.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg		Get quote

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生物&药学活性

RCGD423 (RCGD-423) is a small molecule gp130 modulator that prevents articular cartilage degeneration and promotes repair both in vitro and in vivo.
RCGD423 increases proliferation while reducing apoptosis and hypertrophic responses in adult chondrocytes in vitro, elicits different signalling in chondrocytes than IL-6 family cytokines and can inhibit their catabolic effects.
RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation in rat partial meniscectomy model, improves cartilage healing in rat full-thickness osteochondral defect model.

物理化学性质&存储条件

分子量	331.231
分子式	C15H11BrN2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-bromophenyl)-4-phenylthiazol-2-amine

参考文献

1. Shkhyan R, et al. Ann Rheum Dis. 2018 Feb 7. pii: annrheumdis-2017-212037.

RCGD423 (RCGD-423)

生物&药学活性

物理化学性质&存储条件

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RCGD423 (RCGD-423)

生物&药学活性

物理化学性质&存储条件

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