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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Interleukin Receptor-IRA10L
IRA10L

Chemical Structure : IRA10L

CAS No.:

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IRA10L

货号: PC-26149Not For Human Use, Lab Use Only.

IRA10L is a specific small molecule inhibitor of IL-36 receptor (IL-36R), inhibits IL-36-induced hCXCL1 secretion in HT29 cells with IC50 of 4.72 µM for IL-36γ, 5.81 µM for IL-36α, 14.55 µM for IL-36β, and 6.49 µM for the IL-36α/β/γ cocktail.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

IRA10L is a specific small molecule inhibitor of IL-36 receptor (IL-36R), inhibits IL-36-induced hCXCL1 secretion in HT29 cells with IC50 of 4.72 µM for IL-36γ, 5.81 µM for IL-36α, 14.55 µM for IL-36β, and 6.49 µM for the IL-36α/β/γ cocktail.
IRA10L suppresses multiple IL-36 induced cytokines and signaling pathways.
IRA10L directly binds to IL-36 receptor with SPR KD of 64.1 uM.
IRA10L inhibits IL-36α/β/γ-induced metabolic activity and migration in cancer cells, suppresses IL-36α/β/γ-facilitated spheroid growth.
IRA10L suppresses IL-36-induced colony formation in cancer cells.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Khan AW, et al. Biochem Pharmacol. 2025 Dec 5:117607.

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