| Cat. No. |
Product Name |
Information |
| PC-35927 |
RRx-001
CD47-SIRPα inhibitor
|
RRx-001 (RRx001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity, RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α. |
| PC-62015 |
DRI-C21045
CD40-CD40L inhibitor
|
DRI-C21045 is a novel small-molecule inhibitor of CD40-CD40L protein-protein interaction with IC50 of 0.17 uM in cell-based assays. |
| PC-25299 |
19MS-5
CD28 inhibitor
|
19MS-5 is a specific small molecule CD28 inhibitor, exhibits direct CD28 binding (MST KD=12.48 uM) and potent inhibition of CD28-B7 interactions with IC50 of 5.2 uM in cellular reporter assays. |
| PC-25298 |
5MS-5
CD28 inhibitor
|
5MS-5 is a specific small molecule CD28 inhibitor, exhibits direct CD28 binding (MST KD=50.32 uM) and potent inhibition of CD28-B7 interactions with IC50 of 10.32 uM in cellular reporter assays. |
| PC-25252 |
CD28 inhibitor 22VS
CD28 inhibitor
|
CD28 inhibitor 22VS is a selective small molecule CD28 inhibitor with IC50 of 7.8 uM in ELISA-based CD28:B7-1 (CD80) interaction assays, binds directly to CD28 with MST Kd of 52.45 uM. |
| PC-24096 |
VISTA inhibitor A4
VISTA inhibitor
|
VISTA inhibitor A4 is a potent small molecule inhibitor of VISTA (V-domain Ig suppressor of T cell activation) with binding KD of 0.49 uM. |
| PC-24095 |
VISTA inhibitor B3
VISTA inhibitor
|
VISTA inhibitor B3 is a potent, small molecule inhibitor of V-domain Ig suppressor of T-cell activation (VISTA) with binding KD of 0.452 uM. |
| PC-22968 |
JNU-0921
CD137 agonist
|
JNU-0921 is a specfiic, small molecule CD137 (4-1BB/TNFRSF9) agonist with EC50 of 64 nM in cell-based luciferase assays, activates both human and mouse CD137, directly binds the extracellular domain of CD137, induces CD137 oligomerizationand activates CD137 signaling. |
| PC-22944 |
ICOS inhibitor 9
ICOS/ICOS-L inhibitor
|
ICOS inhibitor 9 is a small molecule inhibitor of ICOS/ICOS-L interaction with IC50 of 29.38 uM. |
| PC-21773 |
CTLA-4 inhibitor A9.1
CTLA-4 inhibitor
|
CTLA-4 inhibitor A9.1 is a small molecule inhibitor of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with IC50 of 1.4 uM in AlphaLISA assays. |
| PC-21772 |
CTLA-4 inhibitor D11.3
CTLA-4 inhibitor
|
CTLA-4 inhibitor D11.3 is a small molecule inhibitor of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with IC50 of 0.97 uM in AlphaLISA assays. |
| PC-21719 |
C-5401331
TIM-3 inhibitor
|
C-5401331 is a small molecule T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) inhibitor, suppresses acute myeloid leukemia (AML) cell proliferation. |
