| Cat. No. |
Product Name |
Information |
| PC-25773 |
CliMB-325
MHC‑I inducer
|
CliMB-325 is a small molecule modulator/ inducer of MHC‑I surface expression, induces MHC-I surface expression levels in CT26 cells with EC50 of 498 nM, also enhances T cell activation and exhibits lower toxicity. |
| PC-25371 |
LAG-3 inhibitor 11
LAG-3 inhibitor
|
LAG-3 inhibitor 11 is a potent, small molecule LAG-3 inhibitor, binds LAG-3 with MST KD of 0.41 uM, demonstrates disruption of the LAG-3/MHC II interaction in a cellular assay with EC50 of 0.31 uM. |
| PC-25299 |
19MS-5
CD28 inhibitor
|
19MS-5 is a specific small molecule CD28 inhibitor, exhibits direct CD28 binding (MST KD=12.48 uM) and potent inhibition of CD28-B7 interactions with IC50 of 5.2 uM in cellular reporter assays. |
| PC-25298 |
5MS-5
CD28 inhibitor
|
5MS-5 is a specific small molecule CD28 inhibitor, exhibits direct CD28 binding (MST KD=50.32 uM) and potent inhibition of CD28-B7 interactions with IC50 of 10.32 uM in cellular reporter assays. |
| PC-25252 |
CD28 inhibitor 22VS
CD28 inhibitor
|
CD28 inhibitor 22VS is a selective small molecule CD28 inhibitor with IC50 of 7.8 uM in ELISA-based CD28:B7-1 (CD80) interaction assays, binds directly to CD28 with MST Kd of 52.45 uM. |
| PC-24096 |
VISTA inhibitor A4
VISTA inhibitor
|
VISTA inhibitor A4 is a potent small molecule inhibitor of VISTA (V-domain Ig suppressor of T cell activation) with binding KD of 0.49 uM. |
| PC-24095 |
VISTA inhibitor B3
VISTA inhibitor
|
VISTA inhibitor B3 is a potent, small molecule inhibitor of V-domain Ig suppressor of T-cell activation (VISTA) with binding KD of 0.452 uM. |
| PC-23564 |
DRI-C21041
CD40-CD40L inhibitor
|
DRI-C21041 is a specific small molecule inhibitor of CD40-CD40L costimulatory interaction with IC50 of 0.31 uM in cell-free in vitro binding inhibition assay. |
| PC-23563 |
DRI-C21095
CD40-CD40L inhibitor
|
DRI-C21095 is a specific small molecule inhibitor of CD40-CD40L costimulatory interaction with IC50 of 0.17 uM in cell-free in vitro binding inhibition assay. |
| PC-22968 |
JNU-0921
CD137 agonist
|
JNU-0921 is a specfiic, small molecule CD137 (4-1BB/TNFRSF9) agonist with EC50 of 64 nM in cell-based luciferase assays, activates both human and mouse CD137, directly binds the extracellular domain of CD137, induces CD137 oligomerizationand activates CD137 signaling. |
| PC-22944 |
ICOS inhibitor 9
ICOS/ICOS-L inhibitor
|
ICOS inhibitor 9 is a small molecule inhibitor of ICOS/ICOS-L interaction with IC50 of 29.38 uM. |
| PC-21817 |
MTX-3937
Siglec-9 inhibitor
|
MTX-3937 is a small-molecule Siglec-9 inhibitor with binding KD of 3.15 uM in BLI assay, inhibits phosphorylation of Siglec-9 and downstream SHP1 and SHP2. |
