CD28 inhibitor 22VS

Chemical Structure : CD28 inhibitor 22VS

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货号: PC-25252Not For Human Use, Lab Use Only.

CD28 inhibitor 22VS is a selective small molecule CD28 inhibitor with IC50 of 7.8 uM in ELISA-based CD28:B7-1 (CD80) interaction assays, binds directly to CD28 with MST Kd of 52.45 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

CD28 inhibitor 22VS is a selective small molecule CD28 inhibitor with IC50 of 7.8 uM in ELISA-based CD28:B7-1 (CD80) interaction assays, binds directly to CD28 with MST Kd of 52.45 uM.
22VS effectively inhibits both CD28-CD80 and CD28-CD86 interactions in a dose-dependent manner, achieving IC50 values of 1.48 uM and 1.39 uM, respectively, in cell-based NanoBit luciferase assays.
22VS specifically inhibits CD28-B7 interactions without inducing nonspecific cytotoxic effects.
22VS inhibits CD28-B7 signaling in reporter- based blockade assay with IC50 of 6.96 uM.
22VS (10-50 uM) demonstrates dose-dependent suppression of T cell activation markers (IFN-γ, IL-2, and sCD69), closely matching the response elicited by the biologic CD28 antagonist FR104.
22VS (10-50 uM) suppresses CD28-dependent cytokine release in a human PBMC-mucosal co-culture model, suppresses CD28-induced cytokine production.

物理化学性质&存储条件

分子量	364.53
分子式	C17H24N4OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(sec-butyl)-2-((5-((4-isopropylphenyl)amino)-1,3,4-thiadiazol-2-yl)thio)acetamide

参考文献

1. Upadhyay S, et al. bioRxiv [Preprint]. 2025 Jul 21:2025.07.16.665260.