19MS-5

Chemical Structure : 19MS-5

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货号: PC-25299Not For Human Use, Lab Use Only.

19MS-5 is a specific small molecule CD28 inhibitor, exhibits direct CD28 binding (MST KD=12.48 uM) and potent inhibition of CD28-B7 interactions with IC50 of 5.2 uM in cellular reporter assays.

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生物&药学活性

19MS-5 is a specific small molecule CD28 inhibitor, exhibits direct CD28 binding (MST KD=12.48 uM) and potent inhibition of CD28-B7 interactions with IC50 of 5.2 uM in cellular reporter assays.
19MS-5 effectively inhibits CD28:B7-1 (CD80) interactions with IC50 of 7.83uM in ELISA-based inhibition assays.
19MS-5 inhibits T cell activation markers in tumor–PBMC co-culture, suppresses CD28-dependent cyto-kine release, including IFN-γ, IL-2, and TNF-α, indicative of strong CD28-mediated T cell activation.

物理化学性质&存储条件

分子量	315.33
分子式	C16H17N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl 3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazole-7-carboxylate

参考文献

1. Upadhyay S, et al. bioRxiv [Preprint]. 2025 Aug 2:2025.07.31.667814.

19MS-5

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19MS-5

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