| Cat. No. |
Product Name |
Information |
| PC-72789 |
NVS-BPTF-1
BPTF bromodomain inhibitor
|
NVS-BPTF-1 is the first highly potent and selective BPTF-bromodomain inhibitor with IC50 of 56 nM in an AlphaScreen assay and Kd of 71 nM in a BLI assay. |
| PC-72779 |
AZ13824374
ATAD2 inhibitor
|
AZ13824374 (AZ 13824374) is a potent and selective ATAD2 bromodomain inhibitor with IC50 of <7 nM. |
| PC-72707 |
TAF1(2) inhibitor 23
TAF1(2) inhibitor
|
TAF1(2) inhibitor 23 is a potent and selective TAF1(2) bromodomain inhibitor with pKi of 9.1, >5000-fold selective over BRD4(1), >50-fold selectivity over the broader bromodomains. |
| PC-72706 |
LM146
PB1 bromodomain inhibitor
|
LM146 (LM-146) is a potent and selective inhibitor of pan-PB1 bromodomains (Polybromo-1 protein, PBRM1 or BAF180), binds to PB1(2), PB1(5), and SMARCA2B with KD values of 110, 61, and 2100 nM, respectively. |
| PC-72676 |
UM-002
BRD4 inhibitor
|
UM-002 is a highly potent, selective, brain penetrant BRD4 bromodomain inhibitor with IC50 of 8.8 and 2.4 nM for BRD4-1 and BRD4-2, respectively. |
| PC-72646 |
I-BET567
pan-BET inhibitor
|
I-BET567 (GSK3383567) is a potent, oral pan-BET inhibitor with Ki of 5-40 nM against BD1/ BD2 of BRD2/3/4/BRDT. |
| PC-72573 |
SR-0813
ENL/AF9 YEATS inhibitor
|
SR-0813 (SR0813) is a potent, selective, dual ENL/AF9 YEATS domain inhibitor (IC50 =25/311 nM). |
| PC-72564 |
CDD-1102
BRDT BD2 inhibitor
|
CDD-1102 (CDD1102) is a potent, selective second bromodomain (BD2) of BRDT and BRD4 inhibitor with IC50 of 7 and 25 nM, >1,000-fold and 300-fold selectivity over BRDT-BD1 and BRD4-BD1. |
| PC-72470 |
GSK789
BET BD1 inhibitor
|
GSK789 (GSK-789) is a potent, cell-permeable, and highly selective inhibitor of the first bromodomains (BD1) of the BET family with IC50 of 20 nM BRD4 BD1, 1500-fold selectivity over BD2. |
| PC-72321 |
BRD8 inhibitor DN02
BRD8 inhibitor
|
BRD8 inhibitor DN02 is a first-in-class selective and cellularly active probe for NuA4 factor BRD8 (BD1) with AlphaScreen IC50 of 48 nM, and Kd of 34 nM. |
| PC-72261 |
BRD4 D1 inhibitor 30
BRD4 D1 inhibitor
|
BRD4 D1 inhibitor 30 is a high-affinity, BRD4 D1-selective chemical probe with Kd of 18 nM, 500-fold selectivity against BRD2 D1 and BRD4 D2. |
| PC-72188 |
BY27
BET BD2 inhibitor
|
BY27 (BD2 inhibitor BY27) is a potent, highly selective BET BD2 inhibitor with Ki of 8.9/8.2/14.2 nM for BRD2/3/4-BD2 respectively. |
