| Cat. No. |
Product Name |
Information |
| PC-45507 |
PFI-4
BRPF1 inhibitor
|
PFI-4 is a potent, selective inhibitor of the BRPF1 bromodomain with pIC50 of 7.3. |
| PC-42109 |
BI-7273
BRD9 inhibitor
|
BI-7273 is a potent, selective and cell-permeable BRD9 bromodomain inhibitor with IC50 of 19 nM in Alpha assay. |
| PC-45780 |
PF-CBP1 hydrochloride
CBP/p300 inhibitor
|
PF-CBP1 hydrochloride is a potent, highly selective inhibitor of the CBP and p300 bromodomains with IC50 of 125 nM and 363 nM, respectively. |
| PC-42090 |
GSK6853
BRPF1 inhibitor
|
GSK6853 (GSK-6853) is a potent, highly selective and cell-active BRPF1 bromodomain inhibitor with TR-FRET pIC50 of 8.1. |
| PC-42168 |
CPI-637
CBP/p300 inhibitor
|
CPI-637 is a potent and selective, cell-active CBP/EP300 bromodomain inhibitor with CBP BRET EC50 of 0.03 uM. |
| PC-43808 |
I-BET726
BET inhibitor
|
I-BET726 (GSK1324726A) is a potent and selective inhibitor of BET bromodomain with IC50 of 41 nM/31 nM/22 nM for BRD2/BRD3/BRD4 respectively. |
| PC-42230 |
TPOP146
CBP/p300 inhibitor
|
TPOP146 is a potent and selective CBP/p300 bromodomain inhibitor with Kd of 134 nM for CBP bromodomain, displays excellent selectivity over other bromodomains (>30-fold over BRD4 (1)). |
| PC-42029 |
Mivebresib
BET inhibitor
|
Mivebresib (ABBV-075) is a potent and orally available BET bromodomain inhibitor with Ki of 1.0, 12.2, 1.5, and 2.2 nM for BRD2, BRD3, BRD4 and BRDT, respectively. |
| PC-26818 |
LS-170
YEATS2 inhibitor
|
LS-170 is a potent, specific inhibitor of ATAC (Ada-two-A-containing) HAT complex subunit YEATS2 with IC50 of 0.14 uM (YEATS2 YEATS domain), shows no inhibitory effect for other YEATS domain family members, AF9, ENL and GAS41. |
| PC-26789 |
CZL-149
BET and p300/CBP inhibitor
|
CZL-149 is a highly potent, orally bioavailable dual inhibitor targeting BET and p300/CBP bromodomains with IC50 of 10.5 nM and 13 nM for p300 and BRD4 BD1 respectively. |
| PC-26728 |
UMB298
CBP/P300 inhibitor
|
UMB298 is a potent, selective CBP/P300 inhibitor with IC50 of 72 nM (CBP), Kd of 315 nM and 215 nM for CBP and EP300, shows 72-fold selectivity over BRD4. |
| PC-26723 |
FRC-303
CHD1 inhibitor
|
FRC-303 (CHD1 inhibitor 2s) is a selective small molecule CHD1 chromodomain inhibitor, targets the H3K4me3 binding site of tandem chromodomain (tCD) with Kd of 0.14 uM. |
