| Cat. No. |
Product Name |
Information |
| PC-60794 |
RO 5126946
α7nAChR PAM
|
RO 5126946 is a potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM. |
| PC-42788 |
ZSET1446
Acetylcholine activator
|
Ismidenon (ZSET1446, ST-101) is a small molecule cognitive enhancer that potentiates acetylcholine-mediated facilitation of inhibitory synaptic transmission in the hippocampal neurons. |
| PC-27340 |
AS3580239
m-nAChR PAM
|
AS3580239 is a positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR), increases ACh-induced current in human myoblasts. |
| PC-27339 |
EC-216
m-nAChR PAM
|
EC-216 is a potent positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR), increases ACh-induced current in human myoblasts, potentiates the muscle ACh receptor through a membrane pocket. |
| PC-27338 |
XG-590
m-nAChR PAM
|
XG-590 (AS3513678) is a positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR), increases ACh-induced current in human myoblasts, potentiates the muscle ACh receptor through a membrane pocket. |
| PC-26760 |
Varenicline Tartrate
α4β2 nAChR agonist
|
Varenicline Tartrate (CP 526555) is a potent, orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR) with IC50 of 250 nM, is also a partial agonist of α6β2 nAChR and a full agonist of α7β2 nAChR. |
| PC-26759 |
Varenicline
α4β2 nAChR agonist
|
Varenicline (CP 526555) is a potent, orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR) with IC50 of 250 nM, is also a partial agonist of α6β2 nAChR and a full agonist of α7β2 nAChR. |
| PC-25970 |
QND8
α7 nAChR agonist
|
QND8 is a selective and potent α7 nAChR agonist, exerts both antinociceptive and anti-inflammatory effects. |
| PC-25934 |
AR-R17779 hydrochloride
α7nAChR agonist
|
AR-R17779 hydrochloride is a potent, selective and full alpha7 nicotinic acetylcholine receptor (α7nAChR) agonist with Ki of 92 nM, >150-fold selective over α4β2 subtype. |
| PC-23918 |
(α4)3(β2)2 nAChR PAM CMPI
(α4)3(β2)2 nAChR PAM
|
CMPI is a subtype-selective positive allosteric modulator (PAM) of nicotinic acetylcholine receptors (nAChRs), preferentially potentiates the (α4)3(β2)2 nAChR with EC50 of 0.26 uM, but not (α4)2(β2)3 nAChR isoforms. |
| PC-23863 |
GTS-21
α7 nAChR agonist
|
GTS-21 (DMXBA) is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist, is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.
GTS-21 (DMXBA) shows anti‑inflammatory and cognition‑enhancing activities. |
| PC-23179 |
SR9883
α4β2* nAChRs enhancer
|
SR9883 is a potent, selective and brain-penetrant enhanceer of α4β2* nAChRs with EC50 of 0.2-0.4 uM, shows no activity against α3β2* or α3β4* nAChRs. |
