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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-nAChR-EC-216
EC-216

Chemical Structure : EC-216

CAS No.:

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EC-216 (EC216)

货号: PC-27339Not For Human Use, Lab Use Only.

EC-216 is a potent positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR), increases ACh-induced current in human myoblasts, potentiates the muscle ACh receptor through a membrane pocket.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

EC-216 is a potent positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR), increases ACh-induced current in human myoblasts, potentiates the muscle ACh receptor through a membrane pocket.

物理化学性质&存储条件

分子量 559.54
分子式 C24H16F3N5O4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-hydroxy-2-methyl-N-(5-(2-phenylpyrimidin-5-yl)-4-(trifluoromethyl)thiazol-2-yl)-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide

参考文献

1. Huanhuan Li, et al. Nature. 2026 Jul 1. doi: 10.1038/s41586-026-10706-1.

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