| Cat. No. |
Product Name |
Information |
| PC-27339 |
EC-216
m-nAChR PAM
|
EC-216 is a potent positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR), increases ACh-induced current in human myoblasts, potentiates the muscle ACh receptor through a membrane pocket. |
| PC-27338 |
XG-590
m-nAChR PAM
|
XG-590 (AS3513678) is a positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR), increases ACh-induced current in human myoblasts, potentiates the muscle ACh receptor through a membrane pocket. |
| PC-26888 |
Salvage-1
α4β2 nAChRs PAM
|
Salvage-1 is a selective, positive allosteric modulator (PAM) of α4β2 nAChRs, demonstrates potent antiarrhythmic efficacy. |
| PC-23864 |
GTS-21 dihydrochloride
α7 nAChR agonist
|
GTS-21 dihydrochloride (DMXBA) is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist, is also an α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist. |
| PC-21718 |
DM506
α7/α9α10 nAChR inhibitor
|
Ibogaminalog (DM506) is a novel ibogamine derivative and inhibitor of α7 and α9α10 nicotinic acetylcholine receptors (nAChRs) with IC50 of 5.1 uM, 5.6 uM and 6.4 uM for α9α10, α7β2 and α7nAChR, respectively. |
| PC-21672 |
BNC210
α7 nAChR PAM
|
Soclenicant (BNC210) is a potent, selective α7 nAChR negative alteration modulator (NAM), inhibits agonist (acetylcholine) induced currents on rat and human α7 nAChRs with EC50 of 1.5 and 3 uM, respectively. |
| PC-21497 |
RGH-560
α7 nAChR PAM
|
RGH-560 (RGH560) is a potent, selective α7 nAChR positive allosteric modulator (PAM) with EC50 of 190 nM (Ca2+-influx). |
| PC-21453 |
CCMI
α7 nAChR PAM
|
CCMI (XY-4083, AVL-3288) is a selective type I α7 nAChR positive allosteric modulator (PAM), evokes positive modulation of EC5 currents induced by acetylcholine ACh, choline, and nicotine with EC50 of 0.7, 0.6 and 0.5 uM, respectively. |
| PC-21112 |
CVN417
α6 nAChR inhibitor
|
CVN417 (CVN-417) is a potent, selective and brain-penetrant α6-containing nicotinic acetylcholine receptor (α6 nAChR) antagonist with Ca2+ flux IC50 of 86 nM. |
| PC-49428 |
AT1001
α3β4 nAChR inhibitor
|
AT1001 (AT-1001) is a high affinity and selective α3β4 nAChR antagonist with Ki value of 2.4 nM, >90-fold selectivity over the other major subtypes (α4β2 and α7 nAChR). |
| PC-49027 |
AN317
α6β2 nAChR agonist
|
AN317 is a functionally selective, partial agonist of α6β2-containing nicotinic acetylcholine receptor (nAChR) with pEC50 of 7.17 (α6/α3β2β3V9'S receptor) in cell-based assays, inhibits the effect of nicotine with IC50 of 1.1 uM. |
| PC-38681 |
Simpinicline
nAChR agonist
|
Simpinicline (OC-02) is a highly selective nicotinic acetylcholine receptor (nAChR) agonist, exhibits potent antiviral activity against the SARS-CoV-2 variants in cell culture with IC50 of 40 nM. |
