| Cat. No. |
Product Name |
Information |
| PC-26293 |
1-NM-PP1
Src inhibitor
|
1-NM-PP1 is a cell-permeable PP1 analog and potent Src family kinases inhibitor with IC50 of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively, also inhibits PKD with IC50 of 398 nM (PKD2) and analog-sensitive CRK9 (CRK9AS). |
| PC-25815 |
DCDBS84
Integrin β3-Src SH3 inhibitor
|
DCDBS84 is a small molecule specifically targeting c-Src SH3 RT-loop with SPR Kd of 0.83 uM, disrupts the interaction of integrin β3 with Src SH3, selectively blocks αIIbβ3 outside-in signaling and shows potent antithrombotic effect. |
| PC-24043 |
Bosutinib hydrate
Src/Abl inhibitor
|
Bosutinib hydrate (SKI-606) is a potent, dual Src/Abl inhibitor with IC50 of 1.2 nM (Src enzyme), inhibits Src autophosphorylation with an IC50 of 0.25 uM in HT29 cells, inhibits bacterially expressed Abl kinase activity with IC50 of 1 nM. |
| PC-24042 |
Bosutinib
Src/Abl inhibitor
|
Bosutinib (SKI-606) is a potent, dual Src/Abl inhibitor with IC50 of 1.2 nM (Src enzyme), inhibits Src autophosphorylation with an IC50 of 0.25 uM in HT29 cells, inhibits bacterially expressed Abl kinase activity with IC50 of 1 nM. |
| PC-49800 |
Toosendanin
Hck/Lyn inhibitor
|
Toosendanin is a small-molecule compound that blocks macrophage-mediated immunosuppression and activates T cells by inhibiting Hck and Lyn kinases, reprograms macrophages to enforce antitumor immunity in glioblastoma (GBM). |
| PC-38544 |
Squarunkin A
UNC119-Src inhibitor
|
Squarunkin A is a small molecule UNC119-cargo interaction inhibitor, selectively inhibits the binding of the N-terminus of Src kinase to UNC119A with IC50 of 10 nM. |
| PC-73124 |
CH6953755
YES1 inhibitor
|
CH6953755 (CH-6953755) is a potent, selective, orally available YES1 kinase inhibitor with IC50 of 1.8 nM. |
| PC-72678 |
iHCK-37
Hck inhibitor
|
iHCK-37 (ASN05260065) is a potent and selective Hck inhibitor with Ki of 0.22 uM. |
| PC-72224 |
DGY-06-116
SRC inhibitor
|
DGY-06-116 (SRC inhibitor 15a) is a potent, selective, covalent Src inhibitor (biochemical IC50=3 nM) that taregrs a P-Loop cysteine (Cys277). |
| PC-72223 |
SM1-71
Multikinase inhibitor
|
SM1-71 is a multi-targeted acrylamide-modified inhibitor that covalently inhibits 23 kinases including MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC (IC50=4 nM), YES1, FGFR1 (IC50=54 nM), ZAK (MLTK), MAP3K1, LIMK1 and RSK2. |
| PC-36164 |
UNC119-Src interaction inhibitor 3
UNC119-Src inhibitor
|
UNC119-Src interaction inhibitor 3 is a potent, specific small molecule inhibitor of UNC119-Src interaction with IC50 of 12 nM for displacement of the Src peptide from UNC119A. |
| PC-35754 |
RK-20449
Hck inhibitor
|
RK-20449 (A419259) is a potent, small molecule inhibitor of hematopoietic cell kinase (HCK) with IC50 of 0.43 nM. |
