| Cat. No. |
Product Name |
Information |
| PC-42595 |
MLN9708
Proteasome inhibitor
|
Ixazomib citrate (MLN9708) is a potent, selective, orally bioavailable proteasome inhibitor with IC50 of 3.4 nM. |
| PC-42470 |
Bortezomib
Proteasome inhibitor
|
Bortezomib (PS341) is a potent, selective, competitive, orally active Proteasome inhibitor with Ki of 0.6 nM for 20S Proteasome. |
| PC-42597 |
Delanzomib
Proteasome inhibitor
|
Delanzomib (CEP18770) is a potent, orally active proteasome inhibitor with IC50 of 3.8 nM against chymotrypsin-like proteasome activity. |
| PC-42598 |
Carfilzomib
Proteasome inhibitor
|
Carfilzomib (PR-171) is a potent, highly selective inhibitor chymotrypsin-like activity of proteasome with IC50 of 6 nM. |
| PC-45547 |
VR23
Proteasome inhibitor, HES1 inhibitor
|
VR23 is a potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM). |
| PC-42242 |
RA190
Rpn13 inhibitor
|
RA190 (RA-190) is a reversible, highly selective, orally active inhibitor of the proteasomal ubiquitin receptor Rpn13, exhibits potent anti-proliferative effects against MM lines (IC50<0.1 uM) and HPV-transformed cells (IC50<0.3 uM). |
| PC-27246 |
YU102
LMP2/Y inhibitor
|
YU102 is a potent, selective dual inhibitor of immunoproteasome (iP) catalytic subunit LMP2 and constitutive proteasome (cP) catalytic subunit Y with IC50 of 105.2 nM (LMP2/β1i) and 206.7 nM (Y/β1), shows no activity against X/β5 and LMP7/β5i. |
| PC-25747 |
PKS3053
β5i inhibitor
|
PKS3053 is a potent, selective inhibitor of immunoproteasome (i-20S) subunit LMP7 (β5i/PSMB8) with IC50 of 0.5 nM, 118-fold selective over constitutive proteasome (c-20S) β5c (PSMB5). |
| PC-24468 |
Lactacystin
Proteasome inhibitor
|
Lactacystin is a potent, orally active, irreversible, cell-permeable, specific proteasome inhibitor (IC50=4.8 uM), also inhibits the lysosomal enzyme cathepsin A, inhibits cell cycle progression and induces neurite outgrowth in murine neuroblastoma cell line. |
| PC-24254 |
Rapaprotin
26S proteasome inhibitor
|
Rapaprotin is a selective apoptosis inducer in multiple myeloma cells (NCI-H929, IC50=156 nM) and 26S proteasome assembly inhibitor. |
| PC-22711 |
Up284
Rpn13 inhibitor
|
Up284 is a small molecule inhibitor of proteasome's 19S Regulatory Particle (RP) ubiquitin receptor RPN13 (ADRM1, hRPN13, or GP110), covalently binds RPN13 and induces rapid apoptosis in ovarian cancer cells. |
| PC-22710 |
RA475
Rpn13 inhibitor
|
RA475 is a small molecule inhibitor of proteasome's 19S Regulatory Particle (RP) ubiquitin receptor RPN13 (ADRM1, hRPN13, or GP110), binds to RPN13 and induces rapid apoptosis in ovarian cancer cells. |
