YU102 | LMP2/Y inhibitor | Probechem Biochemicals

Chemical Structure : YU102

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YU102 (YU-102)

货号: PC-27246Not For Human Use, Lab Use Only.

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生物&药学活性

YU102 is a potent, selective dual inhibitor of immunoproteasome (iP) catalytic subunit LMP2 and constitutive proteasome (cP) catalytic subunit Y with IC50 of 105.2 nM (LMP2/β1i) and 206.7 nM (Y/β1), shows no activity against X/β5 and LMP7/β5i.
YU102 ameliorates AD-related cognitive impairment in the Tg2576 mouse model
YU102 exerts its efficacy independently of Aβ deposition and tau aggregation.
YU102 reduces the numbers of activated astrocytes and microglia in Tg2576 mice.
YU102 attenuates the secretion of pro-inflammatory cytokines from microglia.
YU102 inhibits in vivo and in vitro RPE (retinal pigment epithelium) degeneration in Tg2576 mice.
YU102 has no cytotoxic effect.

物理化学性质&存储条件

分子量	514.62
分子式	C27H38N4O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(acetylglycyl)-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide

参考文献

1. In Jun Yeo, et al. Sci Rep. 2019 Dec 5;9(1):18393.

YU102 (YU-102)

生物&药学活性

物理化学性质&存储条件

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YU102 (YU-102)

生物&药学活性

物理化学性质&存储条件

参考文献

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