| Cat. No. |
Product Name |
Information |
| PC-61304 |
RWJ-56110
PAR-1 antagonist
|
RWJ-56110 (RWJ 56110) is a potent, selective, peptide-mimetic PAR-1 antagonist with binding IC50 of 0.44 uM, with no effect on PAR-2, PAR-3, or PAR-4. |
| PC-60662 |
AC-264613
PAR2 agonist
|
AC-264613 is a novel potent, selective protease-activated receptor PAR2 agonist with potencies ranging from 30-100 nM. |
| PC-60548 |
BMS-986120
PAR4 antagonist
|
BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4. |
| PC-60321 |
AZ3451
PAR2 antagonist
|
AZ3451 (AZ-3451) is a potent, and selective PAR2 antagonist with Kd of 13.5 nM, shows excellent selectivity over PAR1 and PAR4 (>50 uM). |
| PC-60320 |
AZ8838
PAR2 antagonist
|
AZ8838 (AZ-8838) is a potent, and selective PAR2 antagonist with Kd of 125 nM. |
| PC-60319 |
GB-110
PAR2 agonist
|
GB-110 is a potent, non-peptidic agonist of PAR2 that selectively induces PAR2-mediated intracellular Ca(2+) release in HT29 cells with EC50 of 0.28 uM. |
| PC-60318 |
GB-88
PAR2 antagonist
|
GB-88 is a selective, orally available PAR2 antagonist that inhibits PAR2 activated Ca(2+) release with IC50 of 2 uM. |
| PC-42330 |
Vorapaxar
PAR1 antagonist
|
Vorapaxar (SCH 530348) is a potent, selective and orally active thrombin receptor PAR-1 antagonist with Ki of 8.1 nM. |
| PC-47484 |
TRAP-6
PAR-1 agonist
|
TRAP-6 (SFLLRN-OH) is a PAR1 peptide fragment (residues 42-47) that acts as a protease activating receptor 1 (PAR-1) agonist, stimulates platelet aggregation (EC50=0.8 uM). |
| PC-26473 |
PAR-2 inhibitor I-117
PAR-2 antagonist
|
PAR-2 inhibitor I-117 is a potent, selective Protease-Activated Receptor-2 (PAR-2) negative allosteric modulator / antagonist with IC50 of 0.09 nM. |
| PC-23988 |
SLIGRL-NH2
PAR2 agonist
|
SLIGRL-NH2 is an agonist of protease-Activated Receptor-2 (PAR-2). |
| PC-23584 |
Gestodene
PAR1 PAM
|
Gestodene is a progestogen hormonal contraceptive, also is a positive allosteric modulator of PAR1. |
