| Cat. No. |
Product Name |
Information |
| PC-47402 |
Quinidine
|
A class I antiarrhythmic agent (Ia) that works by blocking the fast inward sodium current (INa). |
| PC-24784 |
Zj7923
Kv2.1
|
Zj7923 is a potent, selective voltage-dependent potassium channel Kv2.1 blocker with IC50 of 0.12 uM, >130-fold selectivity for Kv2.1 over Kv1.5, Kv3.1, hERG, TREK-1. |
| PC-24770 |
LPS2336
TREK-1 activator
|
LPS2336 is a potent TREK-1 (K2P2.1) activator with EC50 of 11.76 uM, LPS2336 (50 uM) increases the mean current density recorded at 0 mV in HEK-hTREK-1 cells by 10.77-fold using patch clamp assays. |
| PC-24598 |
TKIM
TREK-1 inhibitor
|
TKIM is a small molecule TREK-1 channel inhibitor with an IC50 of 2.96 μM, binds to the pocket of the intermediate (IM) state of TREK-1. |
| PC-24597 |
ONO-TR-772
TERK inhibitor
|
ONO-TR-772 (VU6018042) is a potent, selective and CNS penetrant TREK (TWIK related K+ channel) inhibitor with IC50 of 15 nM (TREK-1, human manual patch clamp (MPC)), equipotent with TREK-2. |
| PC-24563 |
ROMK inhibitor Compound A
ROMK inhibitor
|
ROMK inhibitor Compound A is a potent, highly selective inhibitor renal outer medullary potassium (ROMK, Kir1.1) channel with IC50 of 24 nM, displays good selectivity across other ion channel superfamilies. |
| PC-24561 |
MK-8153
ROMK inhibitor
|
MK-8153 (MK8153) is a potent, selective inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) with IC50 of 5 nM, 3,400-fold over hERG. |
| PC-24166 |
Opakalim
Kv7 activator
|
Opakalim is a potent, selective small molecule activator of Kv7 potassium channel. |
| PC-23868 |
Ebio2
KCNQ2 activator
|
Ebio2 is a potent, subtype-selective activator of potassium channel KCNQ2 (Kv7.2) with EC50 of 1.9 nM for activation on the outward current amplitude of the KCNQ2 channel at +50 mV. |
| PC-23682 |
Vernakalant hydrochloride
K+ channel blocker
|
Vernakalant (RSD1235) is an atrial-selective antifibrillatory agent and mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker, inhibits wild-type and mutant Kv1.5 channels. |
| PC-23631 |
GiGA1
GIRK1/2 activator
|
GiGA1 is a selective G-protein-independent activator of GIRK channels, targets the alcohol pocket and specifically activates GIRK1/GIRK2 with EC50 of 31 uM. |
| PC-23611 |
VU0134992 hydrochloride
Kir4.1 inhibitor
|
VU0134992 hydrochloride(VU 0134992) is a potent, selective blocker of the inward rectifier potassium channel Kir4.1 (KCNJ10) with IC50 of 0.97 uM in whole-cell patch clamp electrophysiology assays. |
