| Cat. No. |
Product Name |
Information |
| PC-45752 |
Saroglitazar
PPARα agonist
|
Saroglitazar is a PPAR agonist with predominant PPARα and moderate PPARγ activity with EC50 of 0.65 pM and 3 nM respectively. |
| PC-45067 |
Elafibranor
PPARα/δ agonist
|
Elafibranor (GFT505) is a potent dual PPAR α/δ agonist with EC50 of 45 and 175 nM, respectively. |
| PC-45390 |
Pemafibrate
PPARα agonist
|
Pemafibrate (K-877) is a highly potent, specific PPARα agonist with EC50 of 1 nM. |
| PC-27842 |
Pestaphilone U
PPARδ agonist
|
Pestaphilone U (PPU) is a potent anti-ischemic acute kidney injury (AKI) agent, functions as a PPARδ agonist and exerts therapeutic effects against ischemic AKI by modulating reactive oxygen species (ROS). |
| PC-27753 |
Saikosaponin A
PPARγ agonist
|
Saikosaponin A is a triterpenoid saponin derived from Bupleurum root, exhibits neuroprotective and anti-inflammatory properties, modulates neuroprotective pathways associated with transcription factor NURR1 expression. |
| PC-27414 |
Busegampar
PPARγ agonist
|
Busegampar is a potent, selective peroxisome proliferator activated receptor gamma (PPARγ) agonist. |
| PC-26903 |
DTMB
PPAR agonist
|
DTMB is a synthetic tryptophan derivative and PPAR α/δ/γ agonist, binds to PPAR α/δ/γ LBD, ameliorates the chronic inflammation and Aβ pathological progression of Alzheimer’s disease. |
| PC-26571 |
10-oxostearic acid
PPARα agonist
|
10-oxostearic acid (10-oxoSA) is a microbial metabolite derived from oleic acid as a potent and selective agonist of the lipid-sensing nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα), binds to hPPARα-LBD with EC50 of 78.2 nM. |
| PC-26222 |
Pioglitazone
PPARγ agonist
|
Pioglitazone (U 72107) is an orally active and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively, highly selective over PPARα and PPARδ |
| PC-25042 |
Deutaleglitazar
PPARα/γ agonist
|
Deutaleglitazar is the deuterated form of Aleglitazar (R1439, RO 0728804), a potent and balanced dual PPARα/γ agonist (EC50= 50/21 nM). |
| PC-25016 |
SR33068
PPARγ inverse agonist
|
SR33068 is a potent, selective and covalent inverse PPARγ agonist. |
| PC-25015 |
GW9662
PPARγ antagonist
|
GW9662 is a potent and selective PPARγ antagonist with IC50 of 3.3 nM, shows 10 and 1000-fold selectivity over PPARα and PPARδ, respectively. |
