| Cat. No. |
Product Name |
Information |
| PC-62872 |
GW6471
PPARα inhibitor
|
GW6471 is a potent PPARα antagonist with IC50 of 0.24 uM, enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR. |
| PC-62445 |
GW7647
PPARα agonist, USP1 inhibitor
|
GW-7647 is a potent, selective PPARα agonist with EC50 of 6 nM, dispalys high selectivity over PPARγ and PPARδ. |
| PC-62431 |
MCC-555
PPARγ agonist
|
MCC-555 (Isaglitazone, Netoglitazone, RWJ 241947) is an activating ligand of PPARγ with EC50 of 8 uM, exhibts greater antidiabetic potency that other TZDs including BRL49653. |
| PC-62345 |
MRL20
PPARγ agonist
|
MRL20 is a novel synthetic PPARγ ligand and orthosteric agonist with canonical LBP binding affinity of 2 nM. |
| PC-62344 |
SR16832
PPARγ inhibitor
|
SR16832 is a dual-site, covalent and allosteric antagonist of PPARγ, inhibits cellular allosteric activation of PPARγ by rosiglitazone. |
| PC-61631 |
ABTL0812
Akt/mTORC1 inhibitor
|
ABTL0812 (2-hydroxylinoleic acid) is a novel first-in-class, small molecule that inhibits the Akt/mTORC1 axis and shows antiproliferative effect on tumor cells, binds to PPARα and PPARγ (Ki=7.1 and 4.7 uM, respectively). |
| PC-61599 |
T3D-959
PPARγ/δ agonist
|
T3D 959 (DB-959) is a potent, brain penetrant, orally active dual PPARδ/PPARγ agonist with EC50 of 19/297 nM, respectively. |
| PC-61592 |
IVA-337
PPAR agonist
|
IVA-337 (Lanifibranor, IVA337)) is a potent, pan PPAR agonist with EC50 of 0.92 uM, 0.53 uM and 0.18 uM for human PPARα, PPARδ and PPARγ respectively. |
| PC-61381 |
Lenabasum
CB2R antagonist
|
Lenabasum (Ajulemic acid, IP-751, Anabasum) is a synthetic nonpsychoactive cannabinoid acid with potent analgesic and anti-inflammatory activity in vivo, binds directly and selectively to PPARγ. |
| PC-61150 |
Seladelpar
PPARδ agonist
|
Seladelpar (MBX-8025, RWJ800025) is a potent, selective, orally bioavailable PPAR-delta (PPARδ) agonist with EC50 of 2 nM, displays >750-fold selective over PPAR-α. |
| PC-61068 |
BMS-711939
PPARα agonist
|
BMS-711939 (BMS711939) is a potent and selective human PPARα agonist with EC50 of 4 nM, >1,000-fold selectivity over human PPARγ (EC50=4.5 uM) and PPARδ (EC50 >100 uM) in PPAR-GAL4 transactivation assays. |
| PC-60334 |
UHC1
PPARγ ligand
|
UHC1 is a potent, non-agonist PPARγ ligand that blocks CDK5-mediated PPARγ phosphorylation, without the classical agonism. |
