Monocarboxylate Transporter (MCT) (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-28338	VB253 MCT4 inhibitor	VB253 is a potent small molecule inhibitor of monocarboxylate transporter 4 (MCT4, lactate transporter SLC16A3), enhances oxidative phosphorylation, reduces oxidative stress, and decreases glucose metabolite uptake, ameliorates pulmonary fibrosis in vivo.
PC-26721	Silychristin MCT8 inhibitor	Silychristin is a potent specific small molecule inhibitor of thyroid hormone transporter MCT8, inhibits T3 uptake by MCT8 with IC50 of 110 nM.
PC-26718	Syrosingopine MCT1/MCT4 inhibitor	Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, reduces glycolysis and induces synthetic lethality in cancer cells when combine with metformin.
PC-20896	slCeMM1 MCT4 inhibitor	slCeMM1 is a potent, highly selective inhibitor of lactate transporter SLC16A3 (MCT4), inhibits intracellular lactate accumulation in SLC16A3 dependent cells (IC50=91 nM).
PC-49588	AZD0095 MCT4 inhibitor	AZD0095 (AZD-0095) is a potent, selective monocarboxylate transporter 4 (MCT4) inhibitor with IC50 of 1.3 nM, >1000-fold selectivity over MCT1.
PC-49038	MCT4 inhibitor CB-2 MCT4 inhibitor	MCT4 inhibitor CB-2 is a novel small molecule MCT4 inhibitor with significantly inhibitory effect on lactate secretion and striking cytotoxic activity against MDA‐MB‐231 cells.
PC-72709	MSC-4381 MCT4 inhibitor	MSC-4381 (MCT4 inhibitor 18n) is a potent, selective inhibitor of monocarboxylate transporter 4 (MCT4/SLC16A3).
PC-38048	VB124 MCT4 inhibitor	VB124 is a selective, highly potent MCT4 inhibitor, blocks lactate import (IC50 =8.6 nM) and export (IC50=19 nM) in MDA-MB-231 cells.
PC-35589	BAY-8002 MCT1 inhibitor	BAY-8002 (BAY8002) is a potent, selective, orally available monocarboxylate transporter 1 (MCT1) inhibitor (Kd=7.9 nM), inhibits cellular lactate uptake in DLD-1 cells with IC50 of 8 nM.
PC-63259	7ACC2 MCT inhibitor	7ACC2 is a potent inhibitor of mitochondrial pyruvate transport (MPC) and monocarboxylate transporter (MCT) with IC50 of 11 nM for inhibition of [14C]-lactate influx, consecutively blocks extracellular lactate uptake by promoting intracellular pyruvate accumulation.
PC-43427	AR-C155858 MCT1/MCT2 inhibitor	AR-C155858 is a potent monocarboxylate transporter MCT1 and MCT2 with Ki of 2.3 nM and <10 nM, displays no activity at MCT4.
PC-43178	AZD3965 MCT1 inhibitor	AZD3965 (AZD-3965) is a potent, selective, orally bioavailable monocarboxylate transporter 1 (MCT1) inhibitor with binding IC50 of 1.6 nM, displays 6-fold selectivity over MCT2 and does not inhibit MCT3 or MCT4.

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