Silychristin

Chemical Structure : Silychristin

CAS No.: 33889-69-9

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货号: PC-26721Not For Human Use, Lab Use Only.

Silychristin is a potent specific small molecule inhibitor of thyroid hormone transporter MCT8, inhibits T3 uptake by MCT8 with IC50 of 110 nM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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生物&药学活性

Silychristin is a potent specific small molecule inhibitor of thyroid hormone transporter MCT8, inhibits T3 uptake by MCT8 with IC50 of 110 nM.
Silychristin inhibits T3 uptake in primary murine astrocytes expressing endogenous Mct8 but not in MCT10-overexpressing MDCK1-cells. Silychristin is a frequently used adjuvant therapeutic for hepatitis C infection and chronic liver disease.

物理化学性质&存储条件

分子量	482.44
分子式	C25H22O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3R)-3,5,7-Trihydroxy-2-((2R,3S)-7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydrobenzofuran-5-yl)chroman-4-one

参考文献

1. Johannes J, et al. Endocrinology. 2016 Apr;157(4):1694-701.

2. Tan J, et al. Nat Commun. 2025 Mar 26;16(1):2958.

Silychristin

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Silychristin

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