VB253 (VB-253)

Chemical Structure : VB253

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货号: PC-28338Not For Human Use, Lab Use Only.

VB253 is a potent small molecule inhibitor of monocarboxylate transporter 4 (MCT4, lactate transporter SLC16A3), enhances oxidative phosphorylation, reduces oxidative stress, and decreases glucose metabolite uptake, ameliorates pulmonary fibrosis in vivo.

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VB253 is a potent small molecule inhibitor of monocarboxylate transporter 4 (MCT4, lactate transporter SLC16A3), enhances oxidative phosphorylation, reduces oxidative stress, and decreases glucose metabolite uptake, ameliorates pulmonary fibrosis in vivo.

物理化学性质&存储条件

分子量	461.56
分子式	C27H31N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1-(2-(azetidin-1-yl)phenyl)-5-(3-cyclobutoxyphenyl)-1H-pyrazol-3-yl)methoxy)-2-methylpropanoic acid

参考文献

1. Patent US20180162822 A1 2018-06-14.

2. Ziehr DR, et al. Sci Transl Med. 2026 May 6;18(848):eads2673.

VB253 (VB-253)

生物&药学活性

物理化学性质&存储条件

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VB253 (VB-253)

生物&药学活性

物理化学性质&存储条件

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