| Cat. No. |
Product Name |
Information |
| PC-25917 |
GDC-0917
IAP inhibitor
|
GDC-0917 (CUDC-427) is a potent second-generation pan-selective inhibitor of apoptosis (IAP) proteins antagonist with binding affinities to the BIR3 domains of X-IAP and cIAP1/2, and the BIR domain of ML-IAP in the low nanomolar range (Ki < 60 nM). |
| PC-25916 |
GDC-0152
IAP inhibitor
|
GDC-0152 is a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins, binds to XIAP BIR3 domain, BIR domain of ML-IAP, and BIR3 domains of cIAP1 and cIAP2 with Ki of 28, 14, 17, and 43 nM, respectively. |
| PC-25915 |
S-016-1348
SMAC mimetic, XIAP inhibitor
|
S-016-1348 is an orally bioavailable SMAC mimetic compound and inhibitor of XIAP-BIR2 and XIAP-BIR3, promotes cancer cell death independent of TNF-α, upregulates functional DR5 expression in diverse tumor types. |
| PC-25462 |
BI 891065
SMAC mimetic, cIAP1 antagonist
|
BI 891065 is a potent, monovalent, oral SMAC mimetic antagonist of cIAP1 with IC50 of <1 nM, 15 nM and >200 nM for cIAP1, cIAP2, and XIAP respectively. |
| PC-23123 |
IAP antagonist Compound A
IAP Antagonist
|
IAP antagonist Compound A is a highly potent, Smac-mimetic IAP antagonist with equivalent binding affinity to XIAP and cIAP1 in the picomolar range, induces rapid degradation of cIAP1, activates NF-κB signaling via inhibtion of cIAP1 and induces TNFα-dependent apoptosis. |
| PC-22830 |
APG-1387
IAP antagonist
|
Dasminapant (APG-1387) is a bivalent Smac mimetic and antagonist of inhibitor of apoptosis (IAP) proteins, demonstrates potent antitumor activity inducing apoptosis. |
| PC-22252 |
ARTS mimetic B3
ARTS mimetic, XIAP-p53 inhibitor
|
ARTS mimetic B3 is a small-molecule ARTS-mimeticdirectly binds to the ARTS binding pocket in XIAP-BIR3 with KD of 36 uM, stimulates apoptosis in a wide range of cancer cells but not normal PBMC. |
| PC-21421 |
LLP-3
Survivin-Ran inhibitor
|
LLP-3 is a potent inhibitor of Survivin protein interaction, sepcifically inhibits Survivin-Ran complex formation, inhibits glioma stem cells (GSC) survival and growth. |
| PC-20999 |
LBW242
IAP inhibitor
|
LBW242 (LBW-242) is a small molecule Smac-mimetic / inhibitor of apoptosis protein (IAP) antagonist, binds to XIAP (BIR3) with IC50 of 280 nM. |
