BI 891065 | SMAC mimetic, cIAP1 antagonist | Probechem Biochemicals

Chemical Structure : BI 891065

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BI 891065 (BI-891065)

货号: PC-25462Not For Human Use, Lab Use Only.

BI 891065 is a potent, monovalent, oral SMAC mimetic antagonist of cIAP1 with IC50 of <1 nM, 15 nM and >200 nM for cIAP1, cIAP2, and XIAP respectively.

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生物&药学活性

BI 891065 is a potent, monovalent, oral SMAC mimetic antagonist of cIAP1 with IC50 of <1 nM, 15 nM and >200 nM for cIAP1, cIAP2, and XIAP respectively.
BI 891065 exhibits higher affinity toward cIAP1 compared to cIAP2 and more than 200-fold lower affinity toward XIAP.
BI 891065 and BET inhibitor BI 894999 combination induces multiple forms of cell death in vitro.
BI 891065 and BET inhibitor BI 894999 combination is effective in colorectal patient-derived organoid models and in pancreatic and colorectal in vivo xenografts, impairs tumor growth of a pancreatic syngeneic model.

物理化学性质&存储条件

分子量	581.68
分子式	C35H31N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(5-(2-(2-methoxypyridin-3-yl)-7-methylimidazo[1,2-a]pyridin-3-yl)-6-((1-methylisoquinolin-6-yl)ethynyl)pyridin-2-yl)-2-(methylamino)propanamide

参考文献

1. Slavic Obradovic K, et al. Cell Rep Med. 2025 Aug 21:102313.

BI 891065 (BI-891065)

生物&药学活性

物理化学性质&存储条件

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BI 891065 (BI-891065)

生物&药学活性

物理化学性质&存储条件

参考文献

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