| Cat. No. |
Product Name |
Information |
| PC-28284 |
DA-023
EAAT2 PAM
|
DA-023 is a potent, selective positive allosteric modulator (PAM) of excitatory amino acid transporter 2 (EAAT2) with EC50 of 1.0 nM, is inactive against EAAT1 and EAAT3. |
| PC-28283 |
NA-014
EAAT2 PAM
|
NA-014 is a potent, selective positive allosteric modulator (PAM) of excitatory amino acid transporter 2 (EAAT2, rodent homologue glutamate transporter-1, GLT-1) with EC50 of 3.0 nM, is inactive against EAAT1 and EAAT3. |
| PC-25646 |
iMQT_020
SLC1A5_var inhibitor
|
iMQT_020 (iMQT-020) is a first-in-class, selective, noncompetitive allosteric inhibitor of mitochondrial glutamine transporter SLC1A5_var with IC50 of 6.156 uM for mitochondrial glutamine transport, reprograms cancer cell metabolism, impairing both glycolysis and oxidative phosphorylation. |
| PC-20248 |
NV-6297
GLUT-1 inhibitor
|
NV-6297 (NV6297) is a potent, selective mTORC1 pathway signaling inhibitor without inhibition on mTORC2, inhibits S6K1 phosphorylation (pS6K1 T389) in MCF7 cells with IC50 of 120 nM, directly and selectively targets GLUT-1. |
| PC-20247 |
NV-5440
GLUT-1 inhibitor, mTORC1 inhibitor
|
NV-5440 (NV5440) is a potent, selective mTORC1 pathway signaling inhibitor without inhibition on mTORC2, inhibits S6K1 phosphorylation (pS6K1 T389) in MCF7 cells with IC50 of 70 nM, directly targets GLUT-1 with Ki of 69.3 nM. |
| PC-49856 |
GTS467
EAAT2 activator
|
GTS476 (GTS-476) is a potent, selective, orally active activator of EAAT2 with EC50 of 35.1 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2. |
| PC-49855 |
GT949
EAAT2 activator
|
GT949 (GT-949) is a potent, selective activator (positive allosteric modulator) of EAAT2 with EC50 of 0.26 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2. |
| PC-49854 |
GTS511
EAAT2 activator
|
GTS511 (GTS-511) is a potent, selective, brain-permeable activator of EAAT2 with EC50 of 3.8 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2. |
| PC-49853 |
GT951
EAAT2 activator
|
GT951 (GT-951) is a potent, selective activator (positive allosteric modulator) of EAAT2 with EC50 of 0.8 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2. |
| PC-49277 |
(R)-AS-1
EAAT2 PAM
|
(R)-AS-1 is an orally bioavailable, selective positive allosteric modulator (PAM) of the glutamate transporter EAAT2 with EC50 of 11 nM and Emax of 251%, shows potent antiseizure activity in vivo. |
| PC-72279 |
MC-100093
GLT-1 modulator
|
MC-100093 (MC100093) is a potent, orally bioavailable upregulator of glutamate transporter-1 (GLT-1) and devoid of antimicrobial properties. |
| PC-36103 |
Troriluzole
Glutamate modulator
|
Trigriluzole (BHV-4157) is a novel glutamate modulator for the treatment of mild-to-moderate Alzheimer’s disease (AD). |
