| Cat. No. |
Product Name |
Information |
| PC-72250 |
F1957-0088
UHRF1 inhibitor
|
F1957-0088 is a small molecule targeting the UHRF1 tandem Tudor domain (TTD) with TR-FRET (TTD vs. H3K9me3) EC50 of 45.1 uM. |
| PC-72249 |
5A-DMP
UHRF1 inhibitor
|
5A-DMP is a novel TTD-binding compound that binds to tandem Tudor domain (TTD) of UHRF1, inhibits the full-length UHRF1: LIG1 interaction in Xenopus egg extracts. |
| PC-72248 |
UHRF1 inhibitor UM63
UHRF1 inhibitor
|
UHRF1 inhibitor UM63 (UM63) is an anthraquinone compound that binds to the 5-methylcytosine (5mC) binding pocket of the SRA domain of UHRF1, inhibits the base-flipping process, which is crucial in the replication of DNA methylation profiles. |
| PC-72247 |
DNMT3B inhibitor 33h
DNMT3B inhibitor
|
DNMT3B inhibitor 33h is a selective, small molecule inhibitor of DNMT3B with IC50 of 4.8 uM in DRONE assays. |
| PC-72245 |
GSK3484862
DNMT1 inhibitor
|
GSK3484862 (GSK-3484862) is a selective, non-covalent inhibitor of DNMT1, potently inhibits DNMT1 enzymatic activity with IC50 of 0.23 uM. |
| PC-72244 |
GSK3685032
DNMT1 inhibitor
|
GSK3685032 (GSK-3685032) is a potent, first-in-class, highly selective DNMT1 inhibitor with IC50 of 36 nM, >2,500-fold over DNMT3A/3L and DNMT3B/3L. |
| PC-36114 |
Bobcat339
TET inhibitor
|
Bobcat339 (Bobcat 339) is a novel cytosine-based TET enzyme inhibitor with IC50 of 33 uM (TET1) and 73 uM (TET2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a. |
| PC-35290 |
MC3343
DNMT inhibitor
|
MC3343 (MC-3343) is a novel potent, non-nucleoside DNA methyltransferase (DNMT) inhibitor with IC50 of 5.7 and 1.7 uM for DNMT1 and DNMT3a in cell-free assays, respectively. |
| PC-35122 |
NV03
UHRF1 inhibitor
|
NV03 is a small-molecule antagonist of the H3K9me3 binding to UHRF1 tandem tudor domain with Kd of 2.4 uM. |
| PC-35121 |
NV01
UHRF1 inhibitor
|
NV01 is a small-molecule antagonist of the H3K9me3 binding to UHRF1 tandem tudor domain (TTD) with Kd of 5 uM. |
| PC-43175 |
DC-517
DNMT1 inhibitor
|
DC-517 (DC517, DC_517) is a potent, selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 1.7 uM, displays significant selectivity toward other AdoMet-dependent protein methyltransferases. |
| PC-43174 |
DC_05
DNMT1 inhibitor
|
DC_05 is a selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 10.3 uM, displays 3.6-fold selectivity over PRMT1 and >15-fold over DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9.. |
