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首页-小分子抑制剂&激动剂-Epigenetics-DNA Methyltransferase (DNMT)-DC-517
DC-517

Chemical Structure : DC-517

CAS No.: 500017-70-9

DC-517 (DC517, DC_517)

货号: PC-43175Not For Human Use, Lab Use Only.

DC-517 is a potent, selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 1.7 uM, displays significant selectivity toward other AdoMet-dependent protein methyltransferases.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

DC-517 is a potent, selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 1.7 uM, displays significant selectivity toward other AdoMet-dependent protein methyltransferases.
DC-517 significantly inhibits cancer cell proliferation in vitro.

物理化学性质&存储条件

分子量 505.6499
分子式 C33H35N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Propanol, 1-[2-(9H-carbazol-9-yl)-1-(9H-carbazol-9-ylmethyl)ethoxy]-3-[(1-methylethyl)amino]-

参考文献

1. Chen S, et al. J Med Chem. 2014 Nov 13;57(21):9028-41.

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