| Cat. No. |
Product Name |
Information |
| PC-60679 |
TROX-1
Cav2 channels inhibitor
|
TROX-1 is a potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM, compared with hyperpolarized conditions (IC50>20 uM). |
| PC-60006 |
A-1048400
Calcium channel inhibitor
|
A-1048400 is a potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively. |
| PC-45686 |
ABT-639
T-type calcium channel inhibitor
|
ABT-639 is a novel, peripherally acting, selective T-type calcium channel blocker, blocks recombinant human Cav 3.2 in a voltage-dependent fashion (IC50=2 uM). |
| PC-45854 |
NNC 55-0396
T-type calcium channel inhibitor
|
NNC 55-0396 is a potent and selective T-type calcium channel antagonist that blocks recombinant alpha(1)G T-type channels in human embryonic kidney 293 cellswith IC50 of 7 uM. |
| PC-42314 |
MK-8998
T-type calcium channel inhibitor
|
MK-8998 (Suvecaltamide, CX-8998) is a potent and selective antagonist of the T-type calcium channel for the treatment of schizophrenia. |
| PC-44015 |
Diltiazem hydrochloride
L-VDCC inhibitor
|
Diltiazem hydrochloride (CRD-401) is a postsynaptic muscle relaxant that inhibits Ca2+ ions release from sarcoplasmic reticulum stores, inhibits L-type voltage-dependent Ca2+ channels (L-VDCC). |
| PC-42385 |
NS-638
Sodium channel inhibitor
|
NS-638 is a nonpeptide calcium channel blocker that dose dependently inhibits AMPA-stimulated [3H]GABA-release from cultured cortical neurons with IC50 of 4.3 uM. |
| PC-25782 |
Diltiazem
L-VDCC inhibitor
|
Diltiazem (CRD-401) is a postsynaptic muscle relaxant that inhibits Ca2+ ions release from sarcoplasmic reticulum stores, inhibits L-type voltage-dependent Ca2+ channels (L-VDCC). |
| PC-25775 |
Pinokalant
ROCC inhibitor
|
Pinokalant (LOE908, LOE-908) is an inhibitor of receptor-operated Ca(2+) channels (ROCCs) and non-selective cation channel inhibitor, inhibits store-operated Ca2+ entry (SOCE) induced by direct depletion of Ca2+ stores with 100 nM thapsigargin or 100 nM ionomycin with EC50 of 2 uM and 4 uM, respectively. |
| PC-25760 |
TMB-8
Ca2+ antagonist
|
TMB-8 is a specific small molecule Ca 2+ antagonist, interferes with Ca2+ availability in smooth and skeletal muscles. |
| PC-24642 |
Gabapentin
Ca2+ channel blocker, TSP-1 inhibitor
|
Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker, inhibits neuronal Ca2+ influx and reduction of neurotransmitter release, Gabapentin can antagonizes the interaction between thrombospondin-1 (TSP1 and its neuronal receptor alpha2delta1. |
| PC-24535 |
Isradipine
Calcium channel blocker
|
Isradipine (PN 200-110) is a non-selective, orally active L-type calcium channel blocker. Is a powerful peripheral vasodilator and calcium antagonist. |
