AMG1 |CAS:903591-53-7 Probechem Biochemicals

Chemical Structure : AMG1

加入收藏

AMG1 (AMG 1;AMG-1)

货号: PC-60979Not For Human Use, Lab Use Only.

AMG1 is a specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AMG1 is a specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo.
AMG1 potently suppresses SOCE following anti-CD3 stimulation in Th1, Th17 and iTreg cells at 100 nM.
AMG1 strongly reduces SOCE in Th1, Th17 and iTreg cells and significantly attenuates IFN-γ and IL-17 production in human CD4+ T cells with IC50 of 1792 nM and 57 nM, respectively.
AMG1 shows potential for Th1/Th17-mediated autoimmune diseases.

物理化学性质&存储条件

分子量	413.732
分子式	C18H9ClF5N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(2-chloro-5-(trifluoromethyl)phenyl)-2-pyrazinyl)-2,6-difluorobenzamid

参考文献

1. Kaufmann U, et al. J Immunol. 2016 Jan 15;196(2):573-85.

AMG1 (AMG 1;AMG-1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AMG1 (AMG 1;AMG-1)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.