| Cat. No. |
Product Name |
Information |
| PC-70344 |
Deoxygedunin
TrkB agonist
|
Deoxygedunin is a naturally occurring tetranortriterpenoid that has been found to act as a potent, selective, small-molecule agonist of TrkB with Kd of 1.4 uM. |
| PC-60903 |
LOXO-195 R racemate
Trk inhibitor
|
The R racemate of LOXO-195, a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively.. |
| PC-60901 |
Selitrectinib
Trk inhibitor
|
LOXO-195 (Selitrectinib, LOXO195) is a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively. |
| PC-70173 |
Lestaurtinib
JAK2/FLT3 inhibitor
|
Lestaurtinib (KT-5555, CEP-701) is a potent, orally active JAK2, FLT3 and TrkA inhibitor with IC50 of 0.9 nM, 3 nM and < 25 nM, respectively. |
| PC-70172 |
CEP-751
Trk inhibitor
|
CEP-751 (KT-6587) is potent inhibitor of TrkA with IC50 of 2.9 nM, also inhibits TrkB, TrkC. |
| PC-70171 |
K252a
TRK inhibitor
|
K252a (SF2370) is a potent, non-selective tyrosine protein kinase inhibitor for Trk family, CaMK and other phosphorylase kinases. |
| PC-45453 |
GW441756
TrkA inhibitor
|
GW441756 is a potent, specific TrkA inhibitor with IC50 value of 2 nM. |
| PC-23114 |
ACD856
pan-Trk PAM
|
ACD856 is a potent, pan-Trk positive allosteric modulator (PAM) with EC50 of 382 nM, 295 nM and 33 nM for TrkA, TrkB and TrkC respectively. |
| PC-60902 |
LOXO-195 RS-isomer
|
The RS-isomer of LOXO-195, a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively.. |
