| Cat. No. |
Product Name |
Information |
| PC-35729 |
NSC49652
p75NTR agonist
|
NSC49652 (NSC 49652) is a functional p75NTR agonist targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian cells. |
| PC-35679 |
CH7057288
pan-TRK inhibitor
|
CH7057288 (CH-7057288) is a novel potent and selective pan-TRK inhibitor with IC50 of 1.1/7.8/5.1 nM for TRKA/TRKB/TRKC, respectively. |
| PC-63490 |
TrkA-IN-23
TrkA inhibitor
|
TrkA-IN-23 is a highly potent, subtype selective, peripherally restricted, allosteric TrkA inhibitor with IC50 of 10 nM, 180-fold selective over TrkB and 70-fold selective over TrkC in cell based assays. |
| PC-43266 |
LOXO-101 sulfate
TRK inhibitor
|
LOXO-101 (ARRY-470, Larotrectinib) sulfate is potent, selective pan-TRK inhibitor with cellular IC50 of 2-20 nM against TRKA, TRKB, and TRKC kinases. |
| PC-43265 |
LOXO-101
Trk inhibitor
|
LOXO-101 (ARRY-470, Larotrectinib) is potent, selective pan-TRK inhibitor with cellular IC50 of 2-20 nM against TRKA, TRKB, and TRKC kinases. |
| PC-43144 |
Entrectinib
ROS1/TRK/ALK inhibitor
|
Entrectinib (NMS-E628, RXDX-101, NMS-01191372) is a potent, ATP-competitive, orally available pan-TRK, ROS1 and ALK inhibitor with IC50 of 1/3/5/12/7 nM for TRKA/TRKB/TRKC/ALK/ROS1, respectively. |
| PC-63210 |
AZ-23
Trk inhibitor
|
AZ-23 is a potent, selective, orally bioavailable Trk kinase inhibitor with IC50 of 2 and 8 nM for TrkA and TrkB, respectively. |
| PC-43064 |
ANA-12
TrkB antagonist
|
ANA-12 (Ana12) is a selective TrkB antagonist that binds TrkB ECD-Fc with Kd of 12 uM, prevents BDNF-induced neurite outgrowth (at 10 nM), inhibits processes downstream of TrkB without altering TrkA and TrkC functions. |
| PC-63149 |
AZD1332
Trk inhibitor
|
AZD1332 is a potent, selective, ATP-competitive neurotrophic tyrosine kinase receptor (NRTK, TRK) inhibitor with IC50 of <10 nM. |
| PC-62757 |
PQC 083
NGF inhibitor
|
PQC 083 is a novel nerve growth factor (NGF) antagonist with IC50 of 7.0 uM, functionally inhibits NGF's effects on PC12 cell differentiation. |
| PC-61913 |
ALE-0540
NGF antagonist
|
ALE-0540 is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively. |
| PC-61912 |
Ro 08-2750
NGF inhibitor
|
Ro 08-2750 (Ro 082750) is a potent, selective, non-peptide nerve growth factor (NGF) inhibitor that binds to NGF dimer with Kd of 1 uM. |
