| Cat. No. |
Product Name |
Information |
| PC-24089 |
TrkC.T1 antagonist CP14
TrkC.T1 inhibitor
|
Cyclic-14-KI (CP14) is a specific, noncompetitive and allosteric antagonist of TrkC truncated isoform TrkC.T1, selectively antagonize TrkC, reduces CP14 reduces the affinity of NT3 binds to TrkC.T1 with Kd of 11.5 nM. |
| PC-23115 |
ACD855
pan-Trk PAM
|
ACD855 (Ponazuril) is a potent, pan-Trk positive allosteric modulator (PAM) with EC50 of 1.9, 3.2 and 0.8 uM for TrkA, TrkB and TrkC respectively. |
| PC-22603 |
ICP-723
pan-TRK inhibitor
|
Zurletrectinib (ICP-723) is a potent pan-TRK Inhibitor with IC50 of <1 nM for TRKA, TRKB and TRKC, potently inhibits activities of wild-type and some mutant forms of TRK. |
| PC-22476 |
TRK inhibitor 19k
TRK inhibitor
|
TRK inhibitor 19k (Trk-IN-9) is a potent, selective pan tropomyosin receptor kinase (pan-TRK) inhibitor with IC50 of 23/25/21 nM for TRKA/B/C, respectively. |
| PC-22385 |
LM22B-10
TrkB/TrkC agonist
|
LM22B-10 is a small moelcule agonist neurotrophin (NT) receptor TrkB and TrkC, selectively binds to and activates TrkB as well as TrkC, shows neurotrophic activitie. |
| PC-21241 |
PTX-BD10-2
TrkB/C agonist
|
PTX-BD10-2 (BD10-2) is a selective, brain-penetrant small molecule TrkB/C receptor partial agonist, shows survival-promoting activity. |
| PC-20760 |
TrkB agonist R13
TrkB agonist
|
TrkB agonist R13 is a small molecular TrkB receptor agonist prodrug, inhibits asparagine endopeptidase (AEP) and promotes bone formation. |
| PC-20475 |
TrkA inhibitor V1
TrkA inhibitor
|
TrkA inhibitor V1 is an isoform-selective inhibitor of TrkA kinase with IC50 of 199 nM, 470-fold selectivity over TrkB. |
| PC-20031 |
Emzeltrectinib
TrkB inhibitor
|
Emzeltrectinib is a potent, selective neurotrophic factor tyrosine kinase receptor TrkB inhibitor, shows potential for treatment of Trk kinase-mediated tumor. |
| PC-20024 |
Boditrectinib
pan-TRK inhibitor
|
Boditrectinib (AUM-601, NOV1601, HL5101, CHC-2014) is a highly selective, orally administered, which inhibits not only pan-TRK (TRKA, TRKB, and TRKC), but also resistance mutations of TRKs. |
| PC-49205 |
GNF-5837
pan-TRK inhibitor
|
GNF-5837 (GNF5837) is a potent, selective, and orally bioavailable pan-TRK inhibitor with IC50 values of 11/9/7 nM against TRKA/B/C, respectively. |
| PC-49116 |
Anizatrectinib
TrkA inhibitor
|
Anizatrectinib is a potent and orally active inhibitor of TrkA kinase with potential for inflammatory disease such as prostatitis. |
