| Cat. No. |
Product Name |
Information |
| PC-61400 |
Telratolimod
TLR7/8 agonist
|
Telratolimod (MEDI 9197, 3M-052) is a novel, injectable, tissue-retained TLR7/8 agonist that forms a tissue depot with gradual, sustained release, allowing local TLR triggering activity without systemic cytokine release. |
| PC-70318 |
1Z105
TLR4/MD2 ligand
|
1Z105 is a novel synthetic, orally bioavailable TLR4/MD2 ligand, significantly reduces the IL-6 secretion by subsequent challenge with LPS at 0.63 uM. |
| PC-70307 |
TLR7 agonist 54
TLR7 agonist
|
TLR7 agonist 54 is a potent TLR7 agonist with EC50 of 8.6 nM. |
| PC-70306 |
TLR7 agonist 31
TLR7 agonist
|
TLR7 agonist 31 (BBIQ) is a potent TLR7 agonist with EC50 of 59 nM. |
| PC-70305 |
3M-011
TLR7/8 agonist
|
3M-011 is a potent TLR7/8 agonist and cytokine inducer. |
| PC-70304 |
3M-003
TLR7/8 agonist
|
3M-003 is a potent TLR7/8 agonist that induces robust production of the Th1-polarizing cytokines TNF-alpha and IL-12 from neonatal antigen-presenting cells (APCs). |
| PC-70303 |
PF-4878691
TLR7 agonist
|
PF-4878691 (PF-04878691, S32865, 3M-852A) is a selective TLR7 agonist that potently induces IFN-α and IFN-regulated proteins from human PBMC. |
| PC-70302 |
CL075
TLR8 agonist
|
CL075 (3M002) is a selective TLR8 agonist that induces activation of NF-κB at 0.4 uM. |
| PC-61096 |
TLR9 inhibitor 18
TLR9 inhibitor
|
TLR9 inhibitor 18 is a potent, selective TLR9 antagonist with IC50 of 13 nM (human TLR9), displays 75-fold selectivity over TLR7 and no activity against TLR8 (IC50>10 uM). |
| PC-61095 |
CPG-52364
TLR7/8/9 antagonist
|
CPG-52364 (CPG52364) is an orally available, small molecule TLR7/8/9 antagonist for the treatment of systemic lupus erythematosus and other autoimmune disorders.. |
| PC-60332 |
CU-CPT9b
TLR8 inhibitor
|
CU-CPT9b (TLR8 inhibitor 9b) is a potent, selective TLR8 inhibitor with IC50 of 0.7 nM, Kd of 21 nM, and negligible cytotoxicity. |
| PC-60331 |
CU-CPT9a
TLR8 inhibitor
|
CU-CPT9a (TLR8 inhibitor 9a) is a potent, selective TLR8 inhibitor with IC50 of 0.5 nM, and negligible cytotoxicity. |
