| Cat. No. |
Product Name |
Information |
| PC-24818 |
IMID-284
PKM2 inhibitor
|
IMID-284 (IMID284) is a potent, selective pyruvate kinase M2 (PKM2) inhibitor, arrest the progression of IVDD, pain, and inflammation. |
| PC-23535 |
Micheliolide
PKM2 activator
|
Micheliolide (MCL) is a potent, selective and allosteric activator of PKM2, selectively activates pyruvate kinase M2 (PKM2) through the covalent binding at Cys424, effectively promotes the pyruvate kinase activity of rPKM2 with AC50 of 6 nM, shows broad-spectrum anticancer and anti-inflammation activity. |
| PC-23534 |
ACT001
NF-κB inhibitor, PKM2 activator
|
ACT001 (dimethylaminomicheliolide, DMAMCL) is a guaianolide sesquiterpene lactone that targets lasminogen activator inhibitor-1 (PAI-1), also is a a nuclear factor-κB (NF-κB) signaling pathway inhibitor and PKM2 activator, effectively inhibits the proliferation of both tamoxifen-sensitive and tamoxifen-resistant cells. |
| PC-22788 |
Urolithin C
PKL inhibitor
|
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion, Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx, also is an allosteric inhibitor of liver-specific isoform of pyruvate kinase (PKL). |
| PC-22681 |
PKM2 aggregates inhibitor K27
PKM2 aggregates inhibitor
|
PKM2 aggregates inhibitor K27 is a small molecule capable of dissolving PKM2 aggregates and alleviating senescence, restores PKM2 enzymatic activity and glycolytic flux, delays aging of naturally and prematurely aged mice. |
| PC-22680 |
PKM2 aggregates inhibitor K35
PKM2 aggregates inhibitor
|
PKM2 aggregates inhibitor K35 is a small molecule capable of dissolving PKM2 aggregates and alleviating senescence, restores PKM2 enzymatic activity and glycolytic flux, delays aging of naturally and prematurely aged mice. |
